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PROTON – Proton transport and proton-coupled transport

Secure, competitive, and sustainable energy production is a major challenge facing human societies. Biomimetic solutionssuch as the development of new biofuel cells are hampered by our thus far incomplete understanding of proton transferreactions. The same holds for health threats to humanity: Curing diseases like cancer, obesity, chronic gastritis, gastric andduodenal ulcers, requires to pharmacologically interfere - in their molecular details - with yet unresolved proton transferreactions.Here we aim at clarifying the molecular reaction mechanism in the confines of interfacial water layers and proteinaceouscavities with emphasis on arrangement and mobility of proton relay moieties. Achieving this requires an interdisciplinary,multi-level approach comprising cutting edge technologies like second harmonic imaging, single molecule and time resolvedfluorescence microscopy and spectroscopy, advanced calculations of proton transfer, bioengineering of membrane channeland transporter containing systems, synthetic design of biomimetic proton channels, solving protein structures and rational drug design.PROTON will train 15 PhD students, who will acquire a solid state-of-the-art multidisciplinary scientific training in all kinds ofproton migration/reaction systems, covering from basic science to industrial applications, thus preparing them to generatenew scientific knowledge of the highest impact. In addition, practical training on transferable skills will increase theiremployability and qualify them for responsible positions in private and public sectors. Cross-disciplinary strategies and closecollaboration with industry will enable them to resolve the molecular details of proton driven processes in all kinds of settings- enabling the improvement of biomimetic applications – up to fuel cells - and to identify lead substances which may serve topharmacologically interfere with proton transport through membrane channels and transporters.
Koordination an der Vetmeduni Vienna
Pohl Elena
Koordination Gesamtprojekt
Dr. Peter Pohl
Johannes Kepler Universität Linz, Linz, Österreich
Horizon 2020 - Excellent Science - Marie S. Curie (MSCA) - Innovative Training Networks (ITN) H2020
Art der Forschung
Pohl E.,
Beteiligte Vetmed-Organisationseinheiten
Institut für Physiologie, Pathophysiologie und Biophysik, Abteilung für Physiologie und Biophysik
(Weitere) Projektpartner
Kontakt: Dr. Herbert Nar
Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Strasse 173, 55216 Ingelheim am Rhein, Deutschland
Kontakt: Dr. Klaus Weisshart
Carl Zeiss Microscopy GmbH, Carl-Zeiss-Promenade 10, 07745 Jena, Deutschland
Kontakt: Dr. Mihail Barboiu
Centre national de la recherche scientifique, Paris, Frankreich
Kontakt: Prof. Dr. Eric Beitz
Christian-Albrechts-Universität zu Kiel, Christian-Albrechts-Platz 4, 24118 Kiel, Deutschland
Kontakt: Prof. Dr. Andreas Klamt
Cosmologic GmbH & Co KG, Imbacher Weg 46, 51379 Leverkusen, Deutschland
Kontakt: Prof. Sylvie Roke
Ecole Polytechnique Federale de Lausanne, Lausanne, Schweiz
Kontakt: Dr. Federico Thei
Elements SRL, Viale Guglielmo Marconi, 438, 47521 Cesena FC, Italien
Kontakt: Otto Kanzler
Evercyte GmbH, Muthgasse 18, 1190 Wien, Österreich
Kontakt: Prof. Dr. Ana-Nicoleta Bondar
Freie Universität Berlin, Berlin, Deutschland
Kontakt: Dr. Stefan Hannus
Intana Bioscience GmbH, Lochhamer Str. 29, 82152 Planegg, Deutschland
Kontakt: Prof. Martin Hof, DSc.
J. Heyrovský Institute of Physical Chemistry of the CAS, v. v. i., Dolejškova 2155/3, Praha, Tschechische Republik
Kontakt: Dr. Georg Gramse
Keysight Technologies GmbH, Europaplatz 2/1/2, 1150 Wien, Österreich
Kontakt: Prof. Noam Agmon
The Hebrew University of Jerusalem, Jerusalem, Israel
Kontakt: Prof. Dr. Jochen Hub
Universität des Saarlandes, Kirrberger Straße, D Homburg, Saarbrücken, Deutschland
Kontakt: Dr. Hartmut Luecke
UNIVERSITETET I OSLO, Postboks 1072 Blindern, 0316 Oslo, Norwegen
Gefördert durch
EU (Kommission der Europäischen Union), Rue de la Loi, Brussels, Europäische Union

Žuna, K; Jovanović, O; Khailova, LS; Škulj, S; Brkljača, Z; Kreiter, J; Kotova, EA; Vazdar, M; Antonenko, YN; Pohl, EE (2021): Mitochondrial uncoupling proteins (UCP1-UCP3) and adenine nucleotide translocase (ANT1) enhance the protonophoric action of 2,4-dinitrophenol in mitochondria and planar bilayer membranes. Biomolecules. 2021; 11(8):1178
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