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Jak Stat - Signalling from Basis to Disease

Kurzbezeichnung
Jak Stat
Projektkoordination gesamt
Müller Mathias
Laufzeit
01.03.06-29.02.16
Programm
FWF Spezialforschungsbereiche (SFB)
Art der Forschung
Grundlagenforschung
Mitarbeiter/innen
Sexl V., Sub-ProjektleiterIn
Beteiligte Vetmed-Organisationseinheiten
Institut für Pharmakologie und Toxikologie
Institut für Tierzucht und Genetik
Gefördert durch
FWF - Fonds zur Förderung der wissenschaftlichen Forschung, Sensengasse 1, 1090 Wien, Österreich

Link zur Projektdatenbank 'Project Finder'
20 Publikationen

Edlinger, L; Berger-Becvar, A; Menzl, I; Hoermann, G; Greiner, G; Grundschober, E; Bago-Horvath, Z; Al-Zoughbi, W; Hoefler, G; Brostjan, C; Gille, L; Moriggl, R; Spittler, A; Sexl, V; Hoelbl-Kovacic, A (2017): Expansion of BCR/ABL1(+) cells requires PAK2 but not PAK1. Br J Haematol. 2017; 179(2):229-241
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Linke, M; Pham, HT; Katholnig, K; Schnöller, T; Miller, A; Demel, F; Schütz, B; Rosner, M; Kovacic, B; Sukhbaatar, N; Niederreiter, B; Blüml, S; Kuess, P; Sexl, V; Müller, M [and 7 others] (2017): Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol. 2017; 18(3):293-302
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Klose, R; Krzywinska, E; Castells, M; Gotthardt, D; Putz, EM; Kantari-Mimoun, C; Chikdene, N; Meinecke, AK; Schrödter, K; Helfrich, I; Fandrey, J; Sexl, V; Stockmann, C (2016): Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun. 2016; 7:12528
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Bottos, A; Gotthardt, D; Gill, JW; Gattelli, A; Frei, A; Tzankov, A; Sexl, V; Wodnar-Filipowicz, A; Hynes, NE (2016): Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nat Commun. 2016; 7:12258
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Schön K; Schornsteiner E; Dzieciol M; Wagner M; Müller M; Schmitz-Esser S (2016): Microbial communities in dairy processing environment floor-drains are dominated by product-associated bacteria and yeasts. Food Control 2016; 70: 210-215

Maier, BB; Hladik, A; Lakovits, K; Korosec, A; Martins, R; Kral, JB; Mesteri, I; Strobl, B; Müller, M; Kalinke, U; Merad, M; Knapp, S (2016): Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice. Eur J Immunol. 2016; 46(9):2175-2186
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Majoros, A; Platanitis, E; Szappanos, D; Cheon, H; Vogl, C; Shukla, P; Stark, GR; Sexl, V; Schreiber, R; Schindler, C; Müller, M; Decker, T (2016): Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1. EMBO Rep. 2016; 17(3):367-382
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Leitner, NR; Witalisz-Siepracka, A; Strobl, B; Müller, M (2017): Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene. Cytokine. 2017; 89:209-218
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Meissl, K; Macho-Maschler, S; Müller, M; Strobl, B (2017): The good and the bad faces of STAT1 in solid tumours. Cytokine. 2017; 89:12-20
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Shukla, P; Vogl, C; Wallner, B; Rigler, D; Müller, M; Macho-Maschler, S (2015): High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells. BMC Genomics. 2015; 16:944
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Hainzl, E; Stockinger, S; Rauch, I; Heider, S; Berry, D; Lassnig, C; Schwab, C; Rosebrock, F; Milinovich, G; Schlederer, M; Wagner, M; Schleper, C; Loy, A; Urich, T; Kenner, L [and 4 others] (2015): Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis. J Immunol. 2015; 195(10):5011-5024
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Prchal-Murphy, M; Witalisz-Siepracka, A; Bednarik, KT; Putz, EM; Gotthardt, D; Meissl, K; Sexl, V; Müller, M; Strobl, B (2015): In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity. Oncoimmunology. 2015; 4(11):e1047579
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Leopold Wager, CM; Hole, CR; Wozniak, KL; Olszewski, MA; Mueller, M; Wormley, FL (2015): STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans. Infect Immun. 2015; 83(12):4513-4527
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Wienerroither, S; Shukla, P; Farlik, M; Majoros, A; Stych, B; Vogl, C; Cheon, H; Stark, GR; Strobl, B; Müller, M; Decker, T (2015): Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex. Cell Rep. 2015; 12(2):300-312
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Pathria, P; Gotthardt, D; Prchal-Murphy, M; Putz, EM; Holcmann, M; Schlederer, M; Grabner, B; Crncec, I; Svinka, J; Musteanu, M; Hoffmann, T; Filipits, M; Berger, W; Poli, V; Kenner, L [and 8 others] (2015): Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. Oncoimmunology. 2015; 4(4):e998529
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Prchal-Murphy, Michaela (2014): Dissection of kinase-dependent and -independent functions of TYK2 in tumor immune surveillance. Dissertation, Vet. Med. Univ. Wien, pp. 150.

Berger, A; Sexl, V; Valent, P; Moriggl, R (2014): Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia. Oncotarget. 2014; 5(20):9564-9576
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Bosmann, M; Russkamp, NF; Strobl, B; Roewe, J; Balouzian, L; Pache, F; Radsak, MP; van Rooijen, N; Zetoune, FS; Sarma, JV; Núñez, G; Müller, M; Murray, PJ; Ward, PA (2014): Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J Immunol. 2014; 193(11):5668-5677
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Kovacic, B; Hoelbl-Kovacic, A; Fischhuber, KM; Leitner, NR; Gotthardt, D; Casanova, E; Sexl, V; Müller, M (2014): Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells. Haematologica. 2014; 99(6):1006-1015
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Leitner, NR; Lassnig, C; Rom, R; Heider, S; Bago-Horvath, Z; Eferl, R; Müller, S; Kolbe, T; Kenner, L; Rülicke, T; Strobl, B; Müller, M (2014): Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo. PLoS One. 2014; 9(1):e86608
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