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Osteoarthritis-on-a-chip

Abstract
Osteoarthritis (OA) is the most common degenerative arthritic condition and a leading cause of disability worldwide, representing a major health and welfare problem, both in humans and horses (Caron and Genovese 2003; Arden and Nevitt 2006). Although OA is characterized by a failure to repair damaged cartilage, it is a disease of the entire joint, affecting all articular tissues because of their physical and functional association. Currently no therapy is available to stop the progressive degeneration of articular cartilage in OA and to restore damaged cartilage to its original mechanical and functional capacity. Thus there is a large unmet need for a disease-modifying treatment for OA and a corresponding requirement for fit-for- purpose disease models. Although a variety of in vitro OA models are currently published, none of them can comprehensively mimic all facets of OA including the interplay of cartilage and subchondral bone injury/degeneration and synovial inflammation to this extend.In this project we will apply microfluidic technology to primary equine chondrocytes, fibroblast-like synoviocytes and osteoclasts to grow 3D articular microtissues and integrate dynamic mechanical force with the aim to develop a dynamic osteoarthritic joint-on-a-chip to more closely mimic a natural articular environment for pathophysiologic studies and as alternative to animal testing for the development and screening of novel treatment options.
Lemma
Osteoarthritis-on-a-chip
Project leader
Jenner Florien
Duration
01.02.20-31.01.22
Type of Research
Basic research
Vetmed Research Units
University Equine Clinic, Clinical Unit of Equine Surgery
Projekt partner
Contact: Mario Rothbauer
Medizinische Universit├Ąt Wien, Spitalgasse 23, 1090 Wien, Austria
Funded by
Stiftung Pro Pferd, Winterthurerstrasse 260, 8057 Z├╝rich, Switzerland
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