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Secretome versus EVs for tendinopathy

Abstract
Tendinopathy is a chronic painful tendon disorder that is prevalent among sports and pleasure riding horses. No current treatment restores the functional properties of injured tendons resulting in the formation of inferior scarring repair, significantly reduced tendon elasticity, high re-injury rates and chronic morbidity of the horse as well as economic loss of the owners .The repair of adult tendons is slow and inefficient due to the low cellularity, vascularity and metabolic rate of the tendon. It results in a fibrovascular scar that never attains the gross, histological, or mechanical characteristics of normal tendon, leading to high re-injury rates and chronic tendinopathy. In contrast, fetal tendons heal regeneratively without scars even when transplanted into an adult organism. It was shown that adult tenocytes can be induced toward embryonic-like fibrillogenesis, indicating that they may regain regenerative potential. In this proposed study, we will investigate if fetal paracrine MSC derived factors are able to induce a fetal-like response (indicative for fetal like tendon regeneration) of injured adult tenocytes. Furthermore, we will test whether the entire secretome, isolated EVs or soluble factors are required to achieve promising effects for therapeutic applications.
Lemma
Secretome versus EVs for tendinopathy
Project leader
Jenner Florien
Duration
01.02.20-31.01.22
Type of Research
Basic research
Vetmed Research Units
University Equine Clinic, Clinical Unit of Equine Surgery
Projekt partner
Contact: Prof. Johannes Grillari
Ludwig Boltzmann Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, A-1200 Wien, Austria
Funded by
Stiftung Pro Pferd, Winterthurerstrasse 260, 8057 Zürich, Switzerland
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