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Immunometabolic maintenance of tissue integrity

Abstract
Research context: Macrophages are evolutionary old cells that are critical for maintaining tissue integrity by catabolic and anabolic reactions with cells as well as tissue components and the disturbance of macrophage function can promote disease. Recent data indicate that macrophages use different metabolic programs to perform individual effector functions in vitro. However, the role of metabolic signals and the cellular metabolism for macrophage function are multifaceted, complex, and largely unexplored in vivo. The immunometabolic cross-talk of macrophages with tissues remains largely unknown. The comprehensive understanding of immunometabolic functions of macrophages and its communication with tissues in vivo will be of critical importance in identifying new principles how macrophages maintain tissue homeostasis and in the pathogenesis of metabolic diseases such as obesity, type 2 diabetes, cancer, or cachexia. The long-term goal of the SFB IMMUNOMETABOLISM is the discovery of novel therapeutic approaches that target the metabolism and the metabolic signals of macrophages in human disease.Objectives: The SFB IMMUNOMETABOLISM will combine know-how, expertise and join forces to better understand the metabolic interaction between macrophages and tissues for preserving tissue integrity. Within the initial funding period, the SFB IMMUNOMETABOLISM will concentrate on three pivotal objectives:1) Exploration of the immunometabolic profile of macrophage populations in vivo;2) Identification of the metabolic cross-talk of macrophages with tissues in health and disease;3) Manipulate metabolic proteins and pathways of macrophages for functional characterization of immunometabolic regulation in human disease.Approach: The SFB IMMUNOMETABOLISM unites seven established laboratories in Austria with distinguished expertise spanning mouse genetics, energy and lipid metabolism, immunology, biophysics, epigenetics, cell biology, human and mouse organoid cultures and pathology to maximize the potential for successful investigation of the immunological role of metabolism in macrophages in human health and disease.Innovation: We combine unique methodological approaches and expertise to elucidate a novel and innovative biological concept: the maintenance of tissue integrity by macrophages through metabolic cell-cell communication mediated by epigenetic and cellular metabolic adaption.Added value: By uniting different but coherent research groups across Austria through a single, large project grant, we will attain a critical mass and create a center of scientific excellence in Austria for successful international research competition and visibility in the emerging field of immunometabolism.Researchers: Gerda Egger (Medical University of Vienna), Arvand Haschemi (Medical University of Vienna), Christine Moissl-Eichinger (Medical University Graz), Elena Pohl (Veterinary Medical University of Vienna), Gernot Schabbauer (Medical University of Vienna), Martina Schweiger (University Graz), Thomas Weichhart (Medical University of Vienna; Coordinator).
Lemma
Immunometabolism
Coordination for vetmeduni vienna
Pohl Elena
Coordination in general
Gerda EGGER, Arvand HASCHEMI, Gernot SCHABBAUER, Thomas WEICHHART
Medizinische Universität Wien, Spitalgasse 23, 1090 Wien, Austria
Duration
01.03.21-28.02.25
Programme
FWF Spezialforschungsbereich (SFBs) Call 2019
Type of Research
Basic research
Staff
Pohl E.,
Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology and Biophysics
Projekt partner
Contact: Christina MOISSL-EICHINGER
Medizinische Universität Graz, Auenbruggerplatz 2, 8036 Graz, Austria
Contact: Martina SCHWEIGER
Karl-Franzens-Universität Graz, Graz, Austria
Funded by
FWF - Fonds zur Förderung der wissenschaftlichen Forschung, Sensengasse 1, 1090 Wien, Austria

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