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ARCH - Age-Related Changes in Hematopoiesis

Abstract
ARCH is a network of highly qualified experts in experimental hematology created to decipher the causal relationship between the physiological changes in the hematopoietic system during lifespan and the parallel occurrence of specific age- related hematological diseases (pediatric, adult, elderly), with the aim to develop novel targeted therapeutic treatments. ARCH research will integrate the results from complementary model systems (cell lines, mouse models, cells from leukemia patients) and it will deploy a large panel of cutting-edge technologies, such as single cells genomics, epigenomics, genome editing and organoid cultures, in a multi-faceted effort. The ARCH ambitious goal requires scientific and financial resources beyond the capability of a single group. To reach this goal, the ARCH network brings together 15 beneficiaries (12 academic, 2 SMEs and 1 private research institute) and 4 Partner organisations (2 academic, 1 SME and 1 patients’ association). Two European Consortia are present through their italian nodes. ARCH will recruit 15 ESRs that will be all enrolled in PhD programmes. Besides research laboratory work, the ARCH training programme includes scientific, technical and transferable skills courses that will provide ESRs with a solid scientific culture and with awareness of responsible research and innovation issues. This broad portfolio will enable ESRs to become leading academic, clinic or industrial players in the field. The unique combination of scientific excellence, quality of the educational programme and experience in translating basic research into exploitable results will provide ARCH with the real possibility of positively contributing to the enhancement of European competitiveness in the development of innovative, targeted drugs/treatments for hematological diseases, which currently represent a serious socio-economical problem for the European health care system.
Lemma
ARCH
Coordination for vetmeduni vienna
Grebien Florian
Coordination in general
Università degli Studi di Milano-Bicocca, Piazza dell'Ateneo Nuovo, 20126 Mailand, Italy
Duration
01.06.19-31.12.23
Programme
Horizon 2020 - Excellent Science - Marie S. Curie (MSCA) - Innovative Training Networks (ITN) H2020
Type of Research
Basic research
Staff
Grebien F.,
Vetmed Research Units
Institute for Medical Biochemistry
Projekt partner
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON, SORANOU EFESIOU 4, 115 27 Athen, Greece
Diagenode s.a., Rue Bois Saint-Jean, 3, 4102 Seraing (Ougrée), Belgium
FlowMetric Europe, S.p.A., Via Ludovico Ariosto 21, 20091 Bresso, Italy
Fondazione Tettamenti Onlus, Via Giambattista Pergolesi, 33, 20900 Monza, Italy
Institut National de la Sante et de la Recherche Medicale (INSERM), 101 rue de Tolbiac, 75654 Paris, France
Institut Curie, 26 rue d'Ulm / 73 rue Claude Bernard (HQ), 75248 Paris cedex 05, France
King´s College London, De Crespigny Park, GB London, United Kingdom
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Hofgartenstraße 8, 80539 München, Germany
Centre Europeen de Recherche en Biologie et Medecine , 1 rue Laurent Fries, 67404 Illkirch, France
Agencia Estatal Consejo superior de Investigaciones Cientificas, Madrid, Spain
Tel Aviv University, Israel
Universita degli studi di roma la sapienza, Italy
Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands
Funded by
EU (Kommission der Europäischen Union), Rue de la Loi, Brussels, European Union
Publication

Heyes, E; Schmidt, L; Manhart, G; Eder, T; Proietti, L; Grebien, F (2021): Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA-mutated AML. Leukemia. 2021 35 (9) 2526-2538.

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