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WFFS in the horse

The Warmblood fragile foal syndrome (WFFS) is a monogenetic defect with autosomal recessive inheritance. WFFS homozygosity is non-compatible with extra-uterine life. Although up to 15% of Warmblood horses are WFFS carriers, WFFS homozygous foetuses and foals so far have mostly es¬caped veterinary attention. A gene test for the WFFS c.2032G>A mutation of the PLOD1 gene in horses is available and due to fears of an Ehlers-Danlos-like genetic defect, sport horses throughout the world have been tested for WFFS. In Germany, the country with the largest sport horse population in Europe, between 10 to 15% of Warmblood horses are heterozygous and asymptomatic WFFS carriers . A similar percentage of WFFS heterozygous horses can be assumed for Warmbloods worldwide. Our study investigates the hypothesis that WFFS-homozygous equine pregnancies are lost at later stages of pregnancy.
WFFS Pferd
Project leader
Aurich Christine
Type of Research
Applied research
Vetmed Research Units
Graf Lehndorff Institute for Equine Science
Insemination and Embryotransfer Platform
Funded by
Stiftung Brandenburgisches Haupt- und Landgestüt Neustadt (Dosse), Hauptgestüt 10, 16845 Neustadt (Dosse), Germany
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