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WFFS in the horse

Abstract
The Warmblood fragile foal syndrome (WFFS) is a monogenetic defect with autosomal recessive inheritance. WFFS homozygosity is non-compatible with extra-uterine life. Although up to 15% of Warmblood horses are WFFS carriers, WFFS homozygous foetuses and foals so far have mostly es¬caped veterinary attention. A gene test for the WFFS c.2032G>A mutation of the PLOD1 gene in horses is available and due to fears of an Ehlers-Danlos-like genetic defect, sport horses throughout the world have been tested for WFFS. In Germany, the country with the largest sport horse population in Europe, between 10 to 15% of Warmblood horses are heterozygous and asymptomatic WFFS carriers . A similar percentage of WFFS heterozygous horses can be assumed for Warmbloods worldwide. Our study investigates the hypothesis that WFFS-homozygous equine pregnancies are lost at later stages of pregnancy.
Lemma
WFFS Pferd
Project leader
Aurich Christine
Duration
27.08.19-27.02.21
Type of Research
Applied research
Vetmed Research Units
Graf Lehndorff Institute for Equine Science
Insemination and Embryotransfer Platform
Funded by
Stiftung "Brandenburgisches Haupt- und Landgestüt Neustadt (Dosse)", Hauptgestüt 10, 16845 Neustadt (Dosse), Germany
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