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Genome Regulation and Gene Therapy in Human and Veterinary Medicine

Abstract
The programme will cover three logical levels leading from basic laboratory research into applied clinical programmes. The project will focus on:
(1) basic research on the regulation of gene expression as it pertains to (a) potentially therapeutic genes and (b) to (virus) vectors that can be used for therapeutic gene transfer,
(2) translational research moving these findings towards a clinical product that can be used in gene therapy,
(3) clinical research (both human and veterinarian) that will allow the realization of these concepts in the clinical setting.
Work on these three levels will concentrate on five main areas of interest:
- Breast (Breast Cancer)
- Pancreas (Pancreatic Cancer)
- Liver (Liver Cancer; Metabolic Liver Disease)
- Melanoma (Vaccination)
- CNS (Alzheimer)
The concept involves linking the already existent expertise of different institutes and clinics at the University of Veterinary Medicine with external academic and industrial expertise, as well as with clinicians working in the area of human medicine. Ultimately the aim is to move basic research through a translational phase into clinical products in a timely manner.
Financing for the projects comes mainly from extra-University sources such as FFF (in collaboration with Austrianova); WWFF (Innova, Seed Financing); GenAU; Life Sciences Austria; Wirtschaftskammer Förderung; Zweihundert Jahre Wien etc.
17 research areas (A to Q) have been initially identified. These areas form a logical network of existing expertise from within and without the University that will act as a pipeline for new and innovative therapeutic concepts. The concepts will, in the main, be equally applicable to humans and animals, although it is clear that the brunt of the industrial financing will, at least initially, be focussed on the human applications.
Coordination for vetmeduni vienna
Günzburg Walter
Duration
01.01.02-31.12.07
Type of Research
Applied research
Vetmed Research Units
Projekt partner
Euroferm
Krankenhaus Lainz
ISREC Lausanne
JSW Research
Kyushu University
Medizinische Universität Wien, Spitalgasse 23, 1090 Wien, Austria
Max Planck Institut für Molekulare Physiologie, Dortmund, Germany
Paul Ehrlich Institut, Langen
Karl-Franzens-Universität Graz, Graz, Austria
Universität Bochum
Universität Erlangen
Universität Lublin, Polen
Contact: Blaas
Universität Wien, Universitätsring 1, 1010 Wien, Austria
Universitätsklinikum Tübingen, Tübingen, Germany
Funded by
Österreichischer Retriever Club, Zeitlingerberg 11, 4320 Perg, Austria
211 Publications

Tabotta, W; Hohenadl, C; Renner, M; Salmons, B; Günzburg, WH (2003): Reconstituting retroviral vectors allow controlled expression of toxic genes in infected target cells. 11th International Conference on Gene Therapy of Cancer, San Diego, California, DEC 12-14, 2002. Cancer Gene Ther (10) S23-S23.

Holzmüller, H; Renner, M; Stracke, A; Lugauer, M; Salmons, B; Günzburg, WH; Hlavaty, J (2003): Cytochrome P450-based suicide gene therapy using high titer, expression targeted, retroviral vectors. 6th Annual Meeting of the American-Society-of-Gene-Therapy, Washington, DC, JUN 04-08, 2003. Mol Ther (7), 5 S338-S339.

Klein, R; Lipnik, K; Hanak-Hammerl, A; Renner, M; Salmons, B; Günzburg, WH; Hohenadl, C (2003): Mammary gland-specific promoters for targeted breast cancer suicide gene therapy with retroviral vectors. 6th Annual Meeting of the American-Society-of-Gene-Therapy, Washington, DC, JUN 04-08, 2003. Mol Ther (7), 5 S286-S286.

Salmons, B; Hauser, O; Günzburg, WH; Tabotta, W (2007): GMP production of an encapsulated cell therapy product: issues and considerations. BioProcessing Journal (Summer) 36-43.

Paar, M (2007): Effects of viral strain, transgene position and target cell type on the replication kinetics, genomic stability and transgene expression of replication-competent murine leukemia virus-based vectors. Dissertation, Vet. Med. Univ. Wien, pp. k.A..

Wolkerstorfer, A (2007): Establishment of a semi-replicative retroviral vector system for the analysis of putative tissue /tumour specific promoters in vitro and in vivo. Dissertation, Universität für Bodenkultur Wien, pp. 237.

Schlegel, B (2005): The establishment of gag/pol trnasgenic mice as part of an in vivo model to test promoter canditates. Dissertation, Vet. Med. Univ. Wien, pp. 195.

Liehl, B (2005): A lentiviral vector system based on simian immunodeficiency virus for gene transfer into brain cells. Dissertation, Vet. Med. Univ. Wien, pp. 88.

Wolkerstorfer, A; König-Schuster, M; Günzburg, W.H; Salmons, B; Renner, M (2006): Evaluation of tissue/tumour specific promoters in a conditionally replicating retroviral vector system. 14th Congress of the European Society of Gene Therapy , Athens, 9.-12.11.2006. 14th Congress of the European Society of Gene Therapy , Athens, 9.-12.11.2006.

Wolkerstorfer, A; Günzburg, W.H; Salmons, B; Renner, M (2006): A semi-replicative retroviral vector system for efficient evaluation of promoter specificity. Joint Annual Meeting 2006 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Salzburg, 09.2006. Joint Annual Meeting 2006 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Salzburg, 09.2006.

Portsmouth, D; Salmons, B; Günzburg, W.H; Renner, M (2006): Genomic stability of replication-competent Rous sarcoma virus - based vectors is dependent on transgene insertion design. Joint Annual Meeting 2006 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Salzburg, 09.2006. Joint Annual Meeting 2006 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Salzburg, 09.2006.

Paar, M; Ertl, R; Rosenfellner, D; Schwab, S; Salmons, B; Günzburg, WH; Renner, M; Portsmouth, D (2007): Effects of viral strain, transgene position and target cell type on the replication kinetics, genomic stability and transgene expression of replication-competent murine leukaemia virus-based vectors. 99-99.-4th British Society for Gene Therapy Annual Conference ; 19.-21.03.2007 ; Warwick.

Quintino, L; Liehl, B; Moldzio, R; Rosenfellner, D; Salmons, B; Günzburg, WH; Renner, M; Hlavaty, J (2007): Model systems for lentiviral vector mediated therapeutic gene delivery for the treatment of Parkinson's disease. 346-346.-8th International Conference on Alzheimer´s and Parkinson´s disease; 14.-18.03.2007; Salzburg.

Günzburg, W.H; Metzl, C; Paar, M; Mischek, D; Kasahara, N; Salmons, B; Portsmouth, D; Renner, M (2006): Replicating murine leukaemia virus vector configurations: an analysis of stability and tumour selectivity. Japan Conference of the International Society for cell and Gene Therapy of Cancer , Tokyo, 13.-15.10.2006 . Japan Conference of the International Society for cell and Gene Therapy of Cancer , Tokyo, 13.-15.10.2006 .

Portsmouth, D; Hlavaty, J; Renner, M (2007): Suicide genes for cancer therapy. Mol Aspects Med. 2007; 28(1):4-41

Paar, M; Schwab, S; Rosenfellner, D; Salmons, B; Günzburg, WH; Renner, M; Portsmouth, D (2007): Effects of viral strain, transgene position, and target cell type on replication kinetics, genomic stability, and transgene expression of replication-competent murine leukemia virus-based vectors. J Virol. 2007; 81(13):6973-6983
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Liehl, B; Hlavaty, J; Moldzio, R; Tonar, Z; Unger, H; Salmons, B; Günzburg, WH; Renner, M (2007): Simian immunodeficiency virus vector pseudotypes differ in transduction efficiency and target cell specificity in brain. Gene Ther. 2007; 14(18):1330-1343

Steinrigl, A; Ertl, R; Klein, D (2007): Detailed investigation of the retroviral life cycle using real-time PCR assays. 46-46.-3rd International qPCR Symposium; 26.-28.03.2007; Freising.

Agu, CA; Klein, R; Lengler, J; Schilcher, F; Gregor, W; Peterbauer, T; Bläsi, U; Salmons, B; Günzburg, WH; Hohenadl, C (2007): Bacteriophage-encoded toxins: the lambda-holin protein causes caspase-independent non-apoptotic cell death of eukaryotic cells. Cell Microbiol. 2007; 9(7):1753-1765

Steinrigl, A; Salmons, B; Günzburg, W.H; Klein, D (2006): Retroviral vectors harbouring elements from adeno-associated virus to facilitate site-specific integration. XIV Annual Congress of the European Society of Gene Therapy, Athen, 9.-12.11.2006. XIV Annual Congress of the European Society of Gene Therapy, Athen, 9.-12.11.2006.

Günzburg, WH (2006): Cell and gene therapies as medicinal products - is a paradigm change of drug development procedures underway?. Current Opinion in Molecular Therapeutics (8), 4 273-274.

Günzburg, W.H (2006): Past and future clinical trials of NovaCaps. University Clinic Rostock, 12.01.2006. University Clinic Rostock, 12.01.2006.

Günzburg, W.H (2005): Clinical trials of NovaCaps for pancreatic cancer treatment. St Vincents Hospital, Sydney, Australia, 25.11.2005. St Vincents Hospital, Sydney, Australia, 25.11.2005.

Günzburg, W.H (2005): Treating pancreatic cancer with NovaCaps, a novel cell therapy. Western Hospital, Footscray, Melbourne, Australia, 25.11.2005. Western Hospital, Footscray, Melbourne, Australia, 25.11.2005.

Günzburg, W.H (2005): NovaCaps for the treatment of pancreatic cancer. Alfred Hospital, Melbourne, Australia, 24.11.2005. Alfred Hospital, Melbourne, Australia, 24.11.2005.

Hauser, O; Tabotta, W; Schwab, S; Günzburg, W.H; Salmons, B; Holzmüller, H (2006): Encapsulated Cell Therapy for the Treatment of Solid Tumours. Cytotherapy 8,(Suppl. 1).

Hauser, O; Prieschl-Grassauer, E; Tabotta, W; Meier, C; Schwab, S; Günzburg, W.H; Salmons, B; Holzmüller, H (2005): Cell-based therapy with encapsulated cells for the treatment of solid tumours. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Vienna, 26.-28.9.2005. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Vienna, 26.-28.9.2005.

Mischek, D (2006): Establishment of tumor models in immunodeficient mice as a test system for therapeutic retroviral vectors. Dissertation, Vet. Med. Univ. Wien, pp. 143.

Günzburg, W.H; Agu, C.A; Klein, R; Brandtner, E.M; Lengler, J; Ausserlechner, M; Hauser, O; Knapp, E; Bläsi, U; Salmons, B; Hohenadl, C (2006): Ü-holin: a new therapeutic gene to treat tumour cells. 9th International Conference on "Drug and Gene-based Therapeutics", Agia Pelagia, Kreta, 2.-8.09.2006. 9th International Conference on "Drug and Gene-based Therapeutics", Agia Pelagia, Kreta, 2.-8.09.2006.

Salmons, B; Metzl, C; Mischek, D; Kasahara, N; Günzburg, W.H; Portsmouth, D; Renner, M (2006): Tumour selective replicating murine leukaemia virus vectors. 9th International Conference "Gene and Drug Therapy in Molecular Medicine", Agia Pelagia, Crete, Greece, 2.-8.9.2006. 9th International Conference "Gene and Drug Therapy in Molecular Medicine", Agia Pelagia, Crete, Greece, 2.-8.9.2006.

Lengler, J; Omann, M; Düvier, D; Holzmüller, H; Gregor, W; Salmons, B; Günzburg, WH; Renner, M (2006): Cytochrome P450 reductase dependent inhibition of cytochrome P450 2B1 activity: Implications for gene directed enzyme prodrug therapy. Biochem Pharmacol. 2006; 72(7):893-901

Holzmann, C; Dangerfield, JA; López-Lastra, M (2005): Translation of unspliced HIV-1 mRNA is regulated by Rev. XXVII Congreso Chileno De Microbiologia, Pucón-Chile, OCT 13, 2005. Biological Research (38), 2-3 R 156.

Indik, S; Längle-Rouault, F; Dangerfield, JA; Metzner, C; Rungaldier, S; Badhi Nejad Asl, S; Faschinger, A; Salmons, B; Günzburg, WH (2005): Recent advances in the basic biology of mouse mammary tumour virus. XXVII Congreso Chileno De Microbiologia, Pucón-Chile, OCT 13, 2005. Biological Research (38), 2-3 R-21.
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Löhr, M; Günzburg, W (2006): Injection device and method for injecting capsules.

Günzburg, W; Saller, R, Salmons, B (2006): Retroviral Vectors Carrying Senescent Cell Derived Inhibitors 1 (SDI-1) or Antisense SDI-1 Nucleotide Sequences.

Günzburg, W; Saller, R; Salmons, B (2005): Encapsulated Cells Producing Viral Particles.

Günzburg, W; Karle, P; Saller, R (2005): Encapsulated Cells Expressing Cytochrome P450 for Prodrug Activation.

Renner, M (2006): Translation and Commercialisation: Prospects and Hurdles. EU-Workshop "Regenerative Medicine as a challenge for the European Research Area", of the Helmholtz Society, Brussels, 13.02.2006. EU-Workshop "Regenerative Medicine as a challenge for the European Research Area", of the Helmholtz Society, Brussels, 13.02.2006.

Günzburg, W.H (2005): A novel cell therapy for the treatment of pancreatic cancer. Wesley Hospital, Brisbane, Australia, 28.11.2005. Wesley Hospital, Brisbane, Australia, 28.11.2005.

Günzburg, W.H (2005): Efficient infection of human cells by MMTV: a role in mammary cancer?. School of Public Health, University of New South Wales, Sydney, Australia, 25.11.2005. School of Public Health, University of New South Wales, Sydney, Australia, 25.11.2005.

Günzburg, W.H (2005): Pancreatic cancer and NovaCaps. Prince of Wales Hospital, Sydney, Australia, 25.11.2005. Prince of Wales Hospital, Sydney, Australia, 25.11.2005.

Günzburg, W.H (2005): An encapsulated allogeneic cell product for the treatment of pancreatic cancer. New Frontiers in Biomedicine and Biotechnology: opening of the Biotech-Laboratories/Campus Krems, Krems, Austria, 12.11.2005. New Frontiers in Biomedicine and Biotechnology: opening of the Biotech-Laboratories/Campus Krems, Krems, Austria, 12.11.2005.

Salmons, B; Hlavaty, J; Stracke, A; Portsmouth, D; Klein, D; Klein, R; Öztürk-Winder, F; Brandtner, E-M; Tabotta, W; Indik, S; Faschinger, A; Knapp, E; Renner, M; Hohenadl, C; Rouault, F; Günzburg, W.H (2006): MLV and MMTV-based retroviral vectors for safe, efficient and targeted gene therapy: a comprehensive approach. International Society for Cell and Gene Therapy of Cancer, Shenzhen, China, 9.-11.12.05 . International Society for Cell and Gene Therapy of Cancer, Shenzhen, China, 9.-11.12.05 .

Portsmouth, D; Paar, M; Metzl, C; Renner, M; Günzburg, W.H; Salmons, B (2005): Transcriptional targeting of replication competent MLV vectors for cancer gene therapy. 13th Congress of the European Society of Gene Therapy, Prague, Oct 29-Nov 1 2005. 13th Congress of the European Society of Gene Therapy, Prague, Oct 29-Nov 1 2005.

Liehl, B; Überla, K; Unger, H; Salmons, B; Günzburg, W.H; Renner, M (2005): In vivo evaluation of pseudotyped SIV-based lentiviral vectors for gene transfer into the brain. 13th Congress of the European Society of Gene Therapy, Prague, Oct 29-Nov 1 2005. 13th Congress of the European Society of Gene Therapy, Prague, Oct 29-Nov 1 2005.

Günzburg, W.H; Tabotta, W; Kroger, J-C; Löhr, J.M; Holzmüller, H; Prieschl, E; Hauser, O; Hain, J; Saller, R; Losert, U; Renner, M; Hohenadl, C; Salmons, B (2005): Towards a cell therapy product: novel encapsulated allogeneic cells for the treatment of non-resectable pancreatic cancer. International Society for Cell and Gene Therapy of Cancer, Shenzhen, China, 9.-11.12.2005 . International Society for Cell and Gene Therapy of Cancer, Shenzhen, China, 9.-11.12.2005 .

Günzburg, W.H; Faschinger, A; Salmons, B; Indik, S; Rouault, F (2005): Efficient infection of human cells by mouse mammary tumour virus and investigation of integration sites. 17th International Workshop on Retroviral Pathogenesis, St. Malo, France, 1-6.11.2005. 17th International Workshop on Retroviral Pathogenesis, St. Malo, France, 1-6.11.2005.

Brandtner, E.M; Tabotta, W; Kodajova, P; Salmons, B; Günzburg, W.H; Hohenadl, C (2005): A retroviral vector for delivery of directly toxic genes in cancer gene therapy. ESGT Jahrestagung 2005, Prag, 29.10.-1.11.2005. ESGT Jahrestagung 2005, Prag, 29.10.-1.11.2005.

Sakai, S; Kawabata, K; Tanaka, S; Harimoto, N; Hashimoto, I; Mu, C; Salmons, B; Ijima, H; Kawakami, K (2005): Subsieve-size agarose capsules enclosing ifosfamide-activating cells: a strategy toward chemotherapeutic targeting to tumors. Mol Cancer Ther. 2005; 4(11):1786-1790
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Lawson, JS; Günzburg, WH; Whitaker, NJ (2006): Viruses and human breast cancer. Future Microbiol. 2006; 1(1):33-51

Günzburg, W.H; Hlavaty, J; Indik, S; Tabotta, W; Walter, I; Hohenadl, C; Brandtner, EM; Rouault, F; Renner, M; Salmons, B (2006): New generations of retroviral vector for safe, efficient and targeted gene therapy. Journal of Gene Therapy & Molecular Biology (10) 185-192.

Günzburg, WH; Salmons, B (2005): Use of cell therapy as a means of targeting chemotherapy to inoperable pancreatic cancer. Acta Biochim Pol. 2005; 52(3):601-607 Open Access Logo

Günzburg, WH (2005): Oncolytic replicating virus therapy: is the time right? Curr Opin Mol Ther. 2005; 7(4):291-292

Metzner, C; Salmons, B; Gunzburg, WH; Gemeiner, M; Miller, I; Gesslbauer, B; Kungl, A; Dangerfield, JA (2006): MMTV accessory factor Naf affects cellular gene expression. Virology. 2006; 346(1):139-150
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Lipnik, K; Greco, O; Scott, S; Knapp, E; Mayrhofer, E; Rosenfellner, D; Günzburg, WH; Salmons, B; Hohenadl, C (2006): Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors. Virology. 2006; 349(1):121-133
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Klein, R; Ruttkowski, B; Knapp, E; Salmons, B; Günzburg, WH; Hohenadl, C (2006): WPRE-mediated enhancement of gene expression is promoter and cell line specific. Gene. 2006; 372:153-161

Metzl, C; Mischek, D; Salmons, B; Günzburg, WH; Renner, M; Portsmouth, D (2006): Tissue- and tumor-specific targeting of murine leukemia virus-based replication-competent retroviral vectors. J Virol. 2006; 80(14):7070-7078
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Greatorex, JS; Palmer, EA; Pomerantz, RJ; Dangerfield, JA; Lever, AM (2006): Mutation of the Rev-binding loop in the human immunodeficiency virus 1 leader causes a replication defect characterized by altered RNA trafficking and packaging. J Gen Virol. 2006; 87(Pt 10):3039-3044
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Dangerfield, JA; Windbichler, N; Salmons, B; Günzburg, WH; Schröder, R (2006): Enhancement of the StreptoTag method for isolation of endogenously expressed proteins with complex RNA binding targets. Electrophoresis. 2006; 27(10):1874-1877

Günzburg, W; Winder, D; Saller, R (2006): Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy.

Günzburg, W; Salmons, B; Strauss-Goller, S; Klein, D (2006): Targeted Integration into Chromosomes Using Retroviral Vectors.

Stürzl, M; Naschberger, E; Hohenadl, C; Kneser, U; Bauer, M; Hohenberger, W (2005): Das Endothel - ein multifunktionelles Organ: Entdeckung, Funktionen und molekulare Regulation. IN: Krukemeyer, M; Spiegel, H [Hrsg.]: Chirurgische Forschung. Stuttgart, Thieme, pp. 111-127.

Klein, D (2006): Gentherapie. Eingeladener Gastvortrag am BRG Mödling, Mödling, 30.01.2006. Eingeladener Gastvortrag am BRG Mödling, Mödling, 30.01.2006.

Klein, D (2006): Viren als Vektoren in der Gentherapie. 11. Naturwissenschaftlicher Tag am BG 19 Wien , Wien, 01.04.2006. 11. Naturwissenschaftlicher Tag am BG 19 Wien , Wien, 01.04.2006.

Steinrigl, A; Salmons, B; Günzburg, W.H; Klein, D (2006): Inhibition of the retroviral integration machinery as a first step towards targeted integration using chimeric viral vectors. 30. Jahrestagung ÖGHMP, Linz, 29.05.-01.06.2006. 30. Jahrestagung ÖGHMP, Linz, 29.05.-01.06.2006.

Steinrigl, A; Salmons, B; Günzburg, W.H; Klein, D (2006): Inhibition of the retroviral integration machinery as a first step towards targeted integration using chimeric viral vectors. Jahrestagung der Gesellschaft für Virologie, München, 15.-18.03.2006. Jahrestagung der Gesellschaft für Virologie, München, 15.-18.03.2006.

Petznek, H; Hlavaty, J; Url, A; Holzmüller, H; Jandl, G; Salmons, B; Günzburg, W.H; Renner, M (2005): Evaluation of Murine Model Systems of Human Pancreatic Cancer. Joint Annual Meeting of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005. Joint Annual Meeting of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005.

Paar, M; Metzl, C; Renner, M; Günzburg, W.H; Salmons, B; Portsmouth, D (2005): Evaluation of stability and specificity of murine leukemia virus (MLV)-based replication-competent vectors for cancer gene therapy. Joint Annual Meeting of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005. Joint Annual Meeting of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005.

Mörtinger, T; Lipnik, K; Naschberger, E; Stürzl, M; Hatzopoulos, A; Salmons, B; Günzburg, W.H; Hohenadl, C (2006): Anti-angiogenic tumour therapy approach using human GBP-1 as a therapeutic gene. Jahrestagung der Gesellschaft für Virologie, München, 15.-18.03.2006. Jahrestagung der Gesellschaft für Virologie, München, 15.-18.03.2006.

Liehl, B; Überla, K; Unger, H; Salmons, B; Günzburg, W.H; Renner, M (2005): SIV-based lentiviral vectors for gene therapy of brain disorders. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005.

Lengler, J; Holzmüller, H; Düvier, D; Omann, M; Salmons, B; Günzburg, W.H; Renner, M (2005): Cell line dependent action of cytochrome P450 reductase on cytochrome P450 2B1 therapeutic activity. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005.

Hlavaty, J; Jandl, G; König-Schuster, M; Salmons, B; Günzburg, W.H; Renner, M (2005): Envelope selection for retrovirus-mediated gene transfer into human pancreatic cancer cell. 13th Annual congress of the European Society of Gene Therapy , Prag, 29.10.-01.11.2005. 13th Annual congress of the European Society of Gene Therapy , Prag, 29.10.-01.11.2005.

Hlavaty, J; Jandl, G; König-Schuster, M; Salmons, B; Günzburg, W.H; Renner, M (2005): Envelope selection for retrovirus-mediated gene transfer into human pancreatic cancer cells. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005. Joint Annual Meeting 2005 of the ÖGBM, ÖGGGT, ÖGBT, ANGT , Vienna, 26.-28.9.2005.

Rungaldier, S; Nejad Asl, SB; Günzburg, WH; Salmons, B; Rouault, F (2005): Abundant authentic MMTV-Env production from a recombinant provirus lacking the major LTR promoter. Virology. 2005; 342(2):201-214
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Hlavaty, J; Schittmayer, M; Stracke, A; Jandl, G; Knapp, E; Felber, BK; Salmons, B; Günzburg, WH; Renner, M (2005): Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors. Virology. 2005; 341(1):1-11
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Agu, CA; Klein, R; Schwab, S; König-Schuster, M; Kodajova, P; Ausserlechner, M; Binishofer, B; Bläsi, U; Salmons, B; Günzburg, WH; Hohenadl, C (2006): The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models. J Gene Med. 2006; 8(2):229-241

Günzburg, W; Saller, R; Salmons, B (2005): Encapsulated cells producing viral particles.

Günzburg, W; Karle, P; Saller, R; Salmons, B; Löhr, M; Müller, P (2005): Encapsulated cells producing cytochrome P450.

Indik, S; Salmons, B; Günzburg, W. H; Rouault, F (2005): A novel auxiliary protein REM encoded by Mouse Mammary Tumor Virus. Cold Spring Harbor Laboratory Retrovirus Symposium 2005, Cold Spring Harbor, 24.-29.05.2005. Cold Spring Harbor Laboratory Retrovirus Symposium 2005, Cold Spring Harbor, 24.-29.05.2005.

Indik, S; Faschinger, A; Günzburg, W. H; Salmons, B; Rouault, F (2005): Infection of human breast cell lines with MMTV. Cold Spring Harbor Laboratory Retrovirus Symposium 2005, Cold Spring Harbor, 24.-29.05.2005. Cold Spring Harbor Laboratory Retrovirus Symposium 2005, Cold Spring Harbor, 24.-29.05.2005.

Metzner, C (2005): MMTV accessory factor Naf: Molecular Characterisation and host cell response. Diplomarbeit, Univ. Wien, pp. 141.

Agu, CA (2005): Characterisation of the cytotoxic effects of the bacteriophage Lambda-encoded protein on eukaryotic tumour cells. Dissertation, Univ. Wien, pp. 153.

Wolkerstorfer, A; Willner, I.E; Günzburg, W.H; Salmons, B; Renner, M (2005): A semi-replicative retroviral vector system for efficient evaluation of promoter specificity. 12th Annual Meeting of the German Society of Gene Therapy, Würzburg, 29.06.-02.07.2005. 12th Annual Meeting of the German Society of Gene Therapy, Würzburg, 29.06.-02.07.2005.

Salmons, B (2005): A new allogeneic cell therapy product for the treatment of solid tumours. 8th International Conference "Emerging Technologies in Drug and Gene-based Therapeutics", Hersonissos, 03-10.09.05. 8th International Conference "Emerging Technologies in Drug and Gene-based Therapeutics", Hersonissos, 03-10.09.05.

Paar, M; Renner, M; Günzburg, W.H; Salmons, B; Portsmouth, D (2005): Stability of transgene cassette of MLV-based replication-competent retroviruses. Jahrestagung der Gesellschaft für Virologie 2005, Hannover, 16.-19.03.2005. Jahrestagung der Gesellschaft für Virologie 2005, Hannover, 16.-19.03.2005.

Mischek, D; Rosenfellner, D; Zwickl, H; Staettner, S; Metzl, C; Zatloukal, K; Günzburg, W.H; Hohenadl, C (2005): Establishment of molecular characterised human tumour xenograft mouse models for development and evaluation of new tumour therapies. CSHL-Symposium , Cold Spring Harbour, 01.-07.06. 2005. CSHL-Symposium , Cold Spring Harbour, 01.-07.06. 2005.

Metzl, C; Paar, M; Mischek, D; Renner, M; Günzburg, W.H; Salmons, B; Portsmouth, D (2005): Transcriptionally regulated, replication competent retroviral vectors for cancer gene therapy. 12th Annual Meeting of the German Society of Gene Therapy, Würzburg, 29.06.-02.07.2005. 12th Annual Meeting of the German Society of Gene Therapy, Würzburg, 29.06.-02.07.2005.

Lipnik, K; Scott, S; Knapp, E; Rosenfellner, D; Mayrhofer, E; Günzburg, W.H; Salmons, B; Hohenadl, C (2005): Generation of a retroviral vector that confers hypoxia- and radiation-inducible, breast cell specific expression of transferred genes. 3rd Annual workshop , Würzburg, 29.06.-02.07. 2005 . 3rd Annual workshop , Würzburg, 29.06.-02.07. 2005 .

Liehl, B; Überla, K; Unger, H; Salmons, B; Günzburg, W.H; Renner, M (2005): Comprehensive comparison of pseudotyped SIV-based lentiviral vectors for gene transfer into the brain. Jahrestagung der Gesellschaft für Virologie 2005, Hannover, 16.-19.03.2005. Jahrestagung der Gesellschaft für Virologie 2005, Hannover, 16.-19.03.2005.

Lengler, J; Holzmüller, H; Düvier, D; Omann, M; Salmons, B; Günzburg, W.H; Renner, M (2005): Effects of the cytochrome P450 reductase on cytochrome P450 2B1 activity for suicide gene therapy. 12th Annual Meeting of the German Society of Gene Therapy, Würzburg, 29.06.-02.07.2005. 12th Annual Meeting of the German Society of Gene Therapy, Würzburg, 29.06.-02.07.2005.

Günzburg, W.H (2005): New generations of retroviral vector for safe, efficient and targeted gene therapy. 8th International Conference "Emerging Technologies in Drug and Gene-based Therapeutics", Hersonissos, 03-10.09.05. 8th International Conference "Emerging Technologies in Drug and Gene-based Therapeutics", Hersonissos, 03-10.09.05.

Dangerfield, JA; Hohenadl, C; Egerbacher, M; Kodajova, P; Salmons, B; Günzburg, WH (2005): HIV-1 Rev can specifically interact with MMTV RNA and upregulate gene expression. Gene. 2005; 358:17-30

Renner, M (2004): Gentransfer. Kongress für Labordiagnostik und Molekulare Medizin, Salzburg, 09.2004. Kongress für Labordiagnostik und Molekulare Medizin, Salzburg, 09.2004.

Petznek, H; Url, A; Hlavaty, J; Holzmüller, H; Jandl, G; Salmons, B; Günzburg, W.H; Renner, M (2004): Characterisation of in vivo Model Systems of Human Pancreatic Cancer. Annual meeting of the European Pancreas Club, Graz, 07.2004. Annual meeting of the European Pancreas Club, Graz, 07.2004.

Renner, M; Hauser, O; Holzmüller, H; König-Schuster, M; Petznek, H; Prieschl, E; Tabotta, W; Salmons, B; Günzburg, WH (2004): Novel cell based therapy for the treatment of pancreatic cancer. 28th Seminar of the Austrian Society for Surgical Research, Gosau, December 8–10, 2004. European Surgery (36), S201 4-4.

Salmons, B (2005): Phacilitate Cell and Gene Therapy Forum 2005. Cell and gene therapy: a corporate perspective. 24-26 January 2005, Washington, DC, USA. IDrugs (8), 3 203-205.

Salmons, B (2005): Phacilitate Cell and Gene Therapy Forum 2005: Driving gene therapies through preclinical and clinical development. 24-26 January 2005, Washington, DC, USA. IDrugs (8), 3 200-202.

Lengler, J; Holzmüller, H; Salmons, B; Günzburg, WH; Renner, M (2005): FMDV-2A sequence and protein arrangement contribute to functionality of CYP2B1-reporter fusion protein. Anal Biochem. 2005; 343(1):116-124

Indik, S; Günzburg, WH; Salmons, B; Rouault, F (2005): Mouse mammary tumor virus infects human cells. Cancer Res. 2005; 65(15):6651-6659
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Indik, S; Günzburg, WH; Salmons, B; Rouault, F (2005): A novel, mouse mammary tumor virus encoded protein with Rev-like properties. Virology. 2005; 337(1):1-6
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Petznek, H; Url, A; Hlavaty, J; Holzmüller, H; Jandl, G; Salmons, B; Günzburg, W.H; Renner, M (2005): Characterisation of in vivo model systems of human pancreatic cancer. Pancreatology 5 ,(Suppl.1).

Steinrigl, A; Knapp, E; Salmons, B; Günzburg W.H; Klein, D (2005): Inhibition of the retroviral integration machinery as a first step towards targeted integration using chimeric viral vectors. XXII Symposium of the International Association for Comparative Research on Leukemia and Related Diseases, Heidelberg, 02.-05.07.2005. XXII Symposium of the International Association for Comparative Research on Leukemia and Related Diseases, Heidelberg, 02.-05.07.2005.

Lipnik, K; Petznek, H; Renner-Müller, I; Egerbacher, M; Url, A; Salmons, B; Günzburg, WH; Hohenadl, C (2005): A 470 bp WAP-promoter fragment confers lactation independent, progesterone regulated mammary-specific gene expression in transgenic mice. Transgenic Res. 2005; 14(2):145-158

Günzburg, W.H (2004): Cell and gene therapy to improve cancer treatment. Conference on Biotechnology, Wien, 16.11.2004. Conference on Biotechnology, Wien, 16.11.2004.

Günzburg, W.H (2004): Back to basics for the creation of new and improved retroviral vectors. Forschungzentrum Karlsruhe, Karlsruhe, 30.11.2004. Forschungzentrum Karlsruhe, Karlsruhe, 30.11.2004.

Günzburg, W.H; Renner, M; Hauser, O; Holzmüller, H; König-Schuster, M; Petznek, H; Prieschl, E; Tabotta, W; Salmons, B (2004): Novel cell based therapy for the treatment of pancreatic cancer. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004.

Salmons, B (2004): A new strategy for the treatment of pancreatic cancer: towards a phase III clinical trial. Forschungzentrum Karlsruhe, Karlsruhe, 30.11.2004. Forschungzentrum Karlsruhe, Karlsruhe, 30.11.2004.

Hohenadl, C; Winiarczyk,S; Gradski, Z;Michalowski, M; Salmons, B; Günzburg, W.H (2004): Cell based gene therapy of mammary tumors in dogs. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004.

Portsmouth, D (2004): The Austrian Network for Gene Therapy. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004.

Tabotta, W (2004): The impact of the orphan medicinal product designation on clinical study design. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004. 28. Seminar der Österreichische Gesellschaft für Chirugische Forschung , Gosau, 09.12.2004.

Hauser, O; Prieschl-Grassauer, E; Salmons, B (2004): Encapsulated, genetically modified cells producing in vivo therapeutics. Curr Opin Mol Ther. 2004; 6(4):412-420

Günzburg, WH (2004): A milestone year for gene therapy goes unnoticed. Curr Opin Mol Ther. 2004; 6(4):358-359

Günzburg, W.H; Salmons, B (2004): Vectors that repress heterologous promoter activity.

Saller, R.M; Günzburg, W.H; Salmons, B (2004): Encapsulated cells producing viral particles.

Holzmueller, H; Hlavaty, J; Petznek, H; Salmons, B; Guenzburg, W.H; Renner, M (2004): Retroviral vectors for suicide gene therapy of pancreatic tumours. XII Annual Congress of the European Society of Gene Therapy 2004 , Tampere, 04-07.11.2003. XII Annual Congress of the European Society of Gene Therapy 2004 , Tampere, 04-07.11.2003.

Hlavaty, J; Portsmouth, D; Stracke, A; Salmons, B; Günzburg, WH; Renner, M (2004): Effects of sequences of prokaryotic origin on titer and transgene expression in retroviral vectors. Virology. 2004; 330(1):351-360
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Klein, D (1996): Integration Targeting: Establishment and Characterization of a Test-System. EC-Biotechnology Meeting on Somatic Gene Therapy, Venedig, 20.-21.04.1996. EC-Biotechnology Meeting on Somatic Gene Therapy, Venedig, 20.-21.04.1996.

Klein, D (1997): Verwendung von Viren in der Gentherapie. Eingeladener Gastvortrag, Department für Innere Veterinärmedizin der Universität Zürich, 01.07.1997. Eingeladener Gastvortrag, Department für Innere Veterinärmedizin der Universität Zürich, 01.07.1997.

Klein, D (1997): Comparison of marker genes in the context of retroviral vectors. EC-Biotechnology Meeting on Somatic Gene Therapy , Montpellier, 11.-14.09.1997. EC-Biotechnology Meeting on Somatic Gene Therapy , Montpellier, 11.-14.09.1997.

Klein, D (1998): Real-time PCR. EC-Meeting: Cell Based Gene Therapy of Neurodegenrative Diseases, Wien, 27.-28-02.1998. EC-Meeting: Cell Based Gene Therapy of Neurodegenrative Diseases, Wien, 27.-28-02.1998.

Klein, D (1998): Integration targeting using retroviral vectors: Inactivation of the retroviral integrase. EC-Biotechnology Meeting on Somatic Gene Therapy, Berlin, 1.-4.10.98. EC-Biotechnology Meeting on Somatic Gene Therapy, Berlin, 1.-4.10.98.

Klein, D (1998): Verwendung der FACS-Analyse in der Gentherapie. 2. DAKO Flow Cytometry Seminar, Linz, 26.11.98. 2. DAKO Flow Cytometry Seminar, Linz, 26.11.98.

Klein, D (2000): Considerations in the accurate evaluation of retroviral transduction efficiency. EC Biotech Meeting for Cell based Gene Therapy, Wien, 13.-16.01.2000. EC Biotech Meeting for Cell based Gene Therapy, Wien, 13.-16.01.2000.

Klein, D; von Rombs, K; Salmons, B; Günzburg, W.H (1996): Comparison of Marker Genes (GFP and ß-Gal) in the Context of a Retroviral Vector. 8th Workshop on the Pathogenesis of Animal Retroviruses, St. Malo, 23.-25.10.1996. 8th Workshop on the Pathogenesis of Animal Retroviruses, St. Malo, 23.-25.10.1996.

Klein, D; Sölkner, B; Salmons, B; Günzburg, W.H (1998): Comparison of transduction efficiencies estimated by FACS and Real-time PCR. FORGEN Symposium: Genes for Therapy and Prevention of Diseases, Kloster Banz, 27. - 29.09.98. FORGEN Symposium: Genes for Therapy and Prevention of Diseases, Kloster Banz, 27. - 29.09.98.

Günzburg, WH; Klein, D; Mrochen S; Saller, R; Öztürk-Winder; Karle, P; Müller, P; Löhr, M; Salmons, B (1997): Expression targeting of therapeutic genes carried by retroviral vectors to breast and other cancers. IN: Boiron, M [Hrsg.]: Eurocancer 97. Paris, France, John Libbey Eurotext Press, pp. 321-322.

Salmons, B; Saller, RM; Mrochen, S; Öztürk, F; Klein, D; Günzburg, WH (1998): Inducible gene expression from promoter conversion retroviral vectors. IN: Ahmad, F [Hrsg.]: Advances in Gene Technology: Molecular Biology in the Conquest of the disease. Oxford, Oxford University Press, pp. 179-180.

Hohenadl, C (2004): Entwicklung retroviraler Vektoren für die Gentherapie unter Berücksichtigung humaner endogener Retroelemente. Habilitationsschrift, Vet. Med. Univ. Wien, pp. 150.

Hinterreiter S (2004): Analysis of HIV-1 Vpr-mediated infection of differentiated cells using a neuroblastoma cell culture model. Diplomarbeit, Univ. Wien, pp. 114.

Klein, R; Ruttkowski, B; Renner, M; Salmons, B; Günzburg, W.H; Hohenadl, C (2004): Mammary gland-specific retroviral vectors for targeted breast cancer suicide gene therapy. Annual meeting of the American Association for Cancer Research (AACR), Orlando, FL, USA, 27. ¿ 31.03.2004. Annual meeting of the American Association for Cancer Research (AACR), Orlando, FL, USA, 27. ¿ 31.03.2004.

Agu, C.A; Klein, R; Ausserlechner, M; Hauser, O; Bläsi, U; Günzburg, W.H; Salmons, B; Hohenadl, C (2004): Cytotoxic effects of a bacteriophage Lambda-encoded protein in eukaryotic tumor cells. Jahrestagung der OGBM/OGGGT/OGBT/ANGT, Innsbruck, 09/2004. Jahrestagung der OGBM/OGGGT/OGBT/ANGT, Innsbruck, 09/2004.

Klein, R; Ruttkowski, B; Brandtner, E.M; Salmons, B; Günzburg, W.H; Hohenadl, C (2004): Promoter- and cell type-dependent effects of a WPRE on retrovirus-mediated transgene expression. Jahrestagung der OGBM/OGGGT/OGBT/ANGT, Innsbruck, 09/2004. Jahrestagung der OGBM/OGGGT/OGBT/ANGT, Innsbruck, 09/2004.

Klein, D; Tabotta, W; Günzburg, W; Salmons, B (2004): Reconstituting retroviral vector (ReCon vector) for targeted gene expression.

Dangerfield, J (2001): Specific interaction betweeen MMVT sequences and HIV-1 REV promotes efficient RNA export. Dissertation, Univ. Wien, pp. 162.

Hlavaty, J; Stracke, A; Klein, D; Salmons, B; Günzburg, WH; Renner, M (2004): Multiple modifications allow high-titer production of retroviral vectors carrying heterologous regulatory elements. J Virol. 2004; 78(3):1384-1392
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Klein, D; Steinrigl, A; Knapp, E; Brunner, B; Holzweber, A; Leichsenring, B; Nosek, D; Salmons, B; Günzburg, W.H (2004): Molecular epidemiology and replication kinetics of retroviruses. Inaugural Symposium of the new Christian Doppler Laboratory for Gene Therapeutic Vector Development, Wien, 22.-24.01.2004. Inaugural Symposium of the new Christian Doppler Laboratory for Gene Therapeutic Vector Development, Wien, 22.-24.01.2004.

Günzburg, W; Salmons, B; Goller, S; Klein, D (2004): Targeted integration into chromosomes using retroviral vectors.

Lipnik, KM (2003): Identifizierung und Charakterisierung eines brustzellspezifischen Promotors im Kontext eines retroviralen ProCon-Vektors für die Gentherapie von Brustkrebs mit retroviralen Vektoren. Dissertation, Vet. Med. Univ. Wien, pp. 144.

Portsmouth, D (2003): Towards the creation of a transcriptionally regulated, replication competent retroviral vector based on Rous Sarcoma Virus. Dissertation, Univ. Wien, pp. 243.

Rungaldier, S; Günzburg, W.H; Salmons, B; Längle-Rouault, F (2003): MMTV-env production in the absence of P1. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz, Austria, 21. ¿ 24. 09.2003. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz, Austria, 21. ¿ 24. 09.2003.

Indik,S; Günzburg, W.H; Salmons, B; Rouault, F (2003): Infection of Human Cells by Mouse Mammary Tumor Virus. 15th International Workshop on Retroviral Pathogenesis, Glasgow, UK, 17. - 21.09.2003. 15th International Workshop on Retroviral Pathogenesis, Glasgow, UK, 17. - 21.09.2003.

Günzburg, W. H (2003): Cell and gene based therapies to focus and improve efficacy of chemotherapy of solid tumours. Strategies for Organ Repair, Erlangen, Germany, 02.07.2003. Strategies for Organ Repair, Erlangen, Germany, 02.07.2003.

Günzburg, W. H (2003): Retroviral vectors: potential and problems. Childrens Cancer Research Institute, Sankt Anna Kinderspital. Wien, 26.03.2003. Wien, 26.03.2003.

Brandtner, E.M, Tabotta W; Salmons B; Günzburg W.H; Hohenadl C (2003): Reconstructing retroviral vectors for cancer gene therapy. Joint annual Meeting ÖGBM/ÖGGG/ÖGBT/ANGT, Graz, Austria, 21. - 24.09.2003. Joint annual Meeting ÖGBM/ÖGGG/ÖGBT/ANGT, Graz, Austria, 21. - 24.09.2003.

Löhr, M; Hummel, F. Günzburg, W.H; Salmons, B (2003): Experimental treatment of pancreatic cancer. -Disease Progression and Carcinogenesis in the Gastrointestinal Tract; October 9-10, 2002; Freiburg, Germany.

Klein, D; Nosek, D; Leichsenring, B; Knapp, E; Salmons, B; Günzburg, W.H (2003): Directing the integration of retroviral vectors: a new task in vector development. International Journal of Molecular Medicine Vol. 12,(Suppl. 1).

Renner Matthias (2003): GLP, GMP - Umsetzung an Universitäten, SeminarCircle der Life Science Austria Vienna Region: Qualitätssicherung in der Biotechnologie - The magic G`s. Vienna, Austria, 05.2003. Vienna, Austria, 05.2003.

Salmons,B; Hlavaty, J; Leichsenring, B; Stracke, A; Klein, D; Günzburg, W.H; Renner M (2003): Development of high titer, tissue-specific retroviral vector for in vivo tumour therapy. First Workshop of the Study Group in the Society for Virology on viral vectors, Würzburg, Germany, 22.-24.09.2003. First Workshop of the Study Group in the Society for Virology on viral vectors, Würzburg, Germany, 22.-24.09.2003.

Schlegel, B; Willner, I; Kolbe, T; Müller, M; Günzburg, W.H; Salmons, B; Renner M (2003): A novel retroviral vector system for the evaluation of promoter activity and specificity. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz , 21. ¿ 24. 09.2003. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz , 21. ¿ 24. 09.2003.

Günzburg, W; Salmons, B; Baumann, J (2003): Retroviral particles protected against complement mediated destruction.

Liehl, B; Bauer U; Hinterreiter S; Schreiner E; Überla K; Salmons B; Günzburg W.H; Windisch M; Renner M (2003): Lentiviral vectors for gene therapy into neurons in the CNS. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz , 21. ¿ 24. 09.2003. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz , 21. ¿ 24. 09.2003.

Lipnik K; Petznek H; Könikg-Schuster M; Egerbacher M; Walter I; Url A; Renner M; Günzburg W.H; Hohenadl C (2003): Mouse models for breast cancer. AACR Meeting, Mouse models of cancer, Lake Buena Vista, FL, 19.-23.2003. AACR Meeting, Mouse models of cancer, Lake Buena Vista, FL, 19.-23.2003.

Portsmouth, D; Günzburg, W.H; Salmons, B; Renner, M (2003): Towards the creation of a transcriptionally regulated, replication competent, retroviral vector based on Rous Sarcoma Virus. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz, Austria, 21. ¿ 24. 09.2003. Joint Annual Meeting 2003 of the ÖGBM, ÖGGGT, ÖGBT, ANGT, Graz, Austria, 21. ¿ 24. 09.2003.

Dangerfield, J.A; Hohenadl, C; Kodajova, P; Salmons, B; Günzburg, W.H (2003): HIV-1 Rev can directly interact with MMTV RNA and up regulate gene expression. Retroviruses , Cold Spring Harbour, Long Island, New York, USA, 20.05- 26.05.2003. Retroviruses , Cold Spring Harbour, Long Island, New York, USA, 20.05- 26.05.2003.

Diebold, SS; Montoya, M; Unger, H; Alexopoulou, L; Roy, P; Haswell, LE; Al-Shamkhani, A; Flavell, R; Borrow, P; Reis e Sousa, C (2003): Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature. 2003; 424(6946):324-328

Günzburg, WH (2003): Retroviral gene therapy--where now? Trends Mol Med. 2003; 9(7):277-278

Günzburg, WH (2003): Commentary to "Harmful potential of viral vectors fuels doubts over gene therapy". Veterinary Sciences Tomorrow (3).

Löhr, JM; Kröger, JC; Hoffmeyer, A; Freund, M; Hain, J; Holle, A; Knöfel, WT; Liebe, S; Nizze, H; Renner, M; Saller, R; Karle, P; Müller, P; Wagner, T; Hauenstein, K [and 2 others] (2003): Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial. Cancer Therapy (1) 121-131.

Salmons, B; Löhr, M; Günzburg, WH (2003): Treatment of inoperable pancreatic carcinoma using a cell-based local chemotherapy: results of a phase I/II clinical trial. J Gastroenterol. 2003; 38 Suppl 15:78-84

Günzburg, W; Saller, R (2002): Non-self-inactivating Expression of Targeted Retroviral Vectors.

Günzburg, W; Saller, R; Salmons, B (2002): The Use of the WAP and MMTV Regulatory Sequences for Targeted Expression of Linked Heterologues Genes in Human Mammary Cells Including Human Mammary Carcinoma Cells.

Günzburg, W; Saller, R; Salmons, B (2002): Recombinant DNA Vectors for Gene Therapy.

Günzburg, W; Karle, P; Saller, R; Salmons, B; Löhr, M; Müller, P (2003): Encapsulated Cells Producing Cytochrome P450.

Brandtner, E; Tabotta, W; Prieschl, E. E; Agu, C; Salmons, B; Günzburg, W. H; Hohenadl, C (2003): Targeted delivery and tightly controlled expression of transgenes via reconstituting retroviral vectors. Jahrestagung der Gesellschaft für Virologie, Berlin, 26.3. - 29.3.2003. Jahrestagung der Gesellschaft für Virologie, Berlin, 26.3. - 29.3.2003.

Willner, I. E; Schlegel, B; Stracke, A; Günzburg, W. H; Salmons, B; Renner M (2003): A novel retroviral vector system for the evaluation of promoter activity and specifity in vivo. Jahrestagung der Gesellschaft für Virologie, Berlin, 26.3. - 29.3.2003. Jahrestagung der Gesellschaft für Virologie, Berlin, 26.3. - 29.3.2003.

Kröger, JC; Benz, S; Hoffmeyer, A; Bago, Z; Bergmeister, H; Günzburg, WH; Karle, P; Klöppel, G; Losert, U; Müller, P; Nizze, H; Obermaier, R; Probst, A; Renner, M; Saller, R [and 7 others] (2003): Intra-arterial instillation of microencapsulated, Ifosfamide-activating cells in the pig pancreas for chemotherapeutic targeting. Pancreatology. 2003; 3(1):55-63

Salmons, B (2002): Recipes for success? Trends in Molecular Medicine (8) 309-309.

Renner, M (2002): RNA interference, a novel tool for HIV-1 treatment? Trends in Molecular Medicine (8), 9 415-415.
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Petznek, H; Winiarcyk, S; Gradzki, Z; Hain, J; Kammertöns, T; Karle, P; Renner, M; Saller, R; Salmons, B; Günzburg, W (2002): Treatment of canine mammary tumors with encapsulated Cyp2B1 expressing cells. XIth International Conference on Gene Therapy of Cancer, San Diego, USA, DEC 12-14, 2002. Cancer Gene Ther (9), Suppl. 1 33-33.

Gelbmann, W; Klein, D; Walter, I; Müller, M; Fleischmann, M; Hanak-Hammerl, A; Renner, M; Salmons, B; Günzburg, W.H (1999): In Vivo Gene Therapy Models Targeting Metastatic Breast Cancer. 7th Meeting of the European Society of Gene Therapy, München, DE, 1999. The Journal of Gene Medicine 1,(Suppl. 6).

Klein, D; Bugl, B; Günzburg, W.H; Salmons, B (1999): Accurate determination of transduction efficiency by multiplex Real-Time PCR. Seventh Meeting of the European Society of Gene Therapy, Munich, DE. The Journal of Gene Medicine 1,(Suppl. 6).

Klein, D (2000): Quantitative Molekularvirologie: Von der Diagnose zur Gentherapie. Habilitationsschrift, Vet. Med. Univ. Wien, pp. 150.

Klein, D; Bugl, B; Günzburg, W.H; Salmons, B (2000): Gene transfer estimation: comparison of FACS and real-time PCR. XIV Arbeitstagung, Anwendungen der Durchflußzytometrie in der klinischen Zelldiagnostik¿, Regensburg, DE, April 2000. XIV Arbeitstagung, Anwendungen der Durchflußzytometrie in der klinischen Zelldiagnostik¿, Regensburg, DE, April 2000.

Walter, I; Petznek, H; Klein, D; Rigler, D; Müller, M; Salmons, B; Günzburg, W.H; Renner, M. Scanning (2000): Confocal laser scanning microscopy of enhanced green fluorescent protein (EGFP) expression in transgenic mice. San Antonio, Texas, 9.-12.05.2000. Scanning 22,

Klein, D (2000): Gene transfer estimation by multiplex real-time PCR: Advantages and limitations. First International Symposium on Gene Technology and Skin Gene Therapy, Essen, APR 14-15, 2000. Archives of Dermatological Research (292), 4 209-209.

Winiarczyk, S; Gradski, Z; Kosztolich, B; Gabler, C; König, G; Renner, M; Saller, RM; Prosl, H; Salmons, B; Günzburg, WH; Hain, J (2002): A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study. J Mol Med (Berl). 2002; 80(9):610-614

Klein, D; Löhr, M; Karle, P; Renner, M; Saller, R.M; Hain, J; Günzburg, W.H; Salmons, B (2002): Encapsulated cell and retroviral mediated treatment of solid tumors. International Journal of Molecular Medicine 10 ,(Suppl.).

Klein, D (2002): Gene quantification using multiplex real-time PCR: Advantages and limitations. International Symposium on Predictive Oncology and Intervention Strategies, Paris, France, February 9 - 12, 2002. Cancer Detection and Prevention (26), S1 190-190.

Klein, D (2002): Clinical impact of crosstalk during apoptosis induction. Trends in Molecular Medicine (8) 261-262.

Klein, D (2002): Strike against cancer. Trends Mol Med. 2002; 8(1):7

Günzburg, WH; Löhr, M; Salmons, B (2002): Novel treatments and therapies in development for pancreatic cancer. Expert Opin Investig Drugs. 2002; 11(6):769-786

Löhr, JM; Saller, R; Salmons, B; Günzburg, WH (2002): Microencapsulation of genetically engineered cells for cancer therapy. Methods Enzymol (346) 603-618.

Löhr, M; Hummel, F; Faulmann, G; Ringel, J; Saller, R; Hain, J; Günzburg, WH; Salmons, B (2002): Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century. Cancer Chemother Pharmacol. 2002; 49 Suppl 1:S21-S24

Saller, RM; Indraccolo, S; Coppola, V; Esposito, G; Stange, J; Mitzner, S; Amadori, A; Salmons, B; Günzburg, WH (2002): Encapsulated cells producing retroviral vectors for in vivo gene transfer. J Gene Med (4), 2 150-160.

Pambalk, K; Hohenadl, C; Salmons, B; Günzburg, WH; Renner, M (2002): Specific packaging of spliced retroviral vector transcripts lacking the Psi-region. Biochem Biophys Res Commun. 2002; 293(1):239-246

Oztürk-Winder, F; Renner, M; Klein, D; Müller, M; Salmons, B; Günzburg, WH (2002): The murine whey acidic protein promoter directs expression to human mammary tumors after retroviral transduction. Cancer Gene Ther (9), 5 421-431.
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Armeanu, S; Haessler, I; Saller, R; Engelmann, MG; Heinemann, F; Krausz, E; Stange, J; Mitzner, S; Salmons, B; Günzburg, WH; Nikol, S (2001): In vivo perivascular implantation of encapsulated packaging cells for prolonged retroviral gene transfer. J Microencapsul. 2001; 18(4):491-506

Uckert, W; Becker, C; Gladow, M; Klein, D; Kammertoens, T; Pedersen, L; Blankenstein, T (2000): Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype. Hum Gene Ther. 2000; 11(7):1005-1014

Walter, I; Fleischmann, M; Klein, D; Müller, M; Salmons, B; Günzburg, WH; Renner, M; Gelbmann, W (2000): Rapid and sensitive detection of enhanced green fluorescent protein expression in paraffin sections by confocal laser scanning microscopy. Histochem J. 2000; 32(2):99-103

Klein, D; Bugl, B; Günzburg, WH; Salmons, B (2000): Accurate estimation of transduction efficiency necessitates a multiplex real-time PCR. Gene Ther. 2000; 7(6):458-463
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Steinborn, R; Zakhartchenko, V; Jelyazkov, J; Klein, D; Wolf, E; Müller, M; Brem, G (1998): Composition of parental mitochondrial DNA in cloned bovine embryos. FEBS Lett. 1998; 426(3):352-356

Günzburg, WH; Karle, P; Mrochen, S; Sparmann, G; Saller, R; Klein, D; Uckert, W; Salmons, B (1998): Regulated gene expression after retroviral vector-mediated delivery of cancer-relevant therapeutic genes. Recent Results Cancer Res. 1998; 144:11-26

Klein, D; Salmons, B; Günzburg, WH (1997): Comparison of viral vectors: Implications for gene therapy. BIOforum International (1) 104-109.

Mrochen, S; Klein, D; Nikol, S; Smith, JR; Salmons, B; Günzburg, WH (1998): Inducible expression of p21WAF-1/CIP-1/SDI-1 from a promoter conversion retroviral vector. J Mol Med (75), 11-12 820-828.

Klein, D; Indraccolo, S; von Rombs, K; Amadori, A; Salmons, B; Günzburg, WH (1997): Rapid identification of viable retrovirus-transduced cells using the green fluorescent protein as a marker. Gene Ther. 1997; 4(11):125-160
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Klein, D; Knapp, E; Fröschl, N; Salmons, B; Günzburg, W.H (2001): Gene transfer estimation and optimisation using multiplex real-time PCR: Advantages and limitations. Gentherapie in Österreich, Wien, AT, 6.03.2001 . Gentherapie in Österreich, Wien, AT, 6.03.2001 .

Willner, I; Stracke, A; Günzburg, W.H; Salmons, B; Renner, M (2001): A semi-replicative retroviral vector model system. 9th Meeting of the European Society of Gene Therapy, Antalya, TR, 2. - 4.11.2001. 9th Meeting of the European Society of Gene Therapy, Antalya, TR, 2. - 4.11.2001.

Tabotta, W; Öztürk-Winder, F; Hohenadl, C; Renner, M; Salmons, B; Günzburg, W.H (2001): MLV-based retroviral vectors for tightly controlled mammary cell-specific gene expression. Vector Targeting Therapeutic Strategies for Gene Therapy, Cold Spring Harbor, USA, 15.-18.03.2001. Vector Targeting Therapeutic Strategies for Gene Therapy, Cold Spring Harbor, USA, 15.-18.03.2001.

Pambalk, K; Salmons, B; Günzburg, W.H; Renner, M (2001): Influence of splicing on retroviral vectors. Jahrestagung der Gesellschaft für Virologie, Dresden, DE, 13.-17.03.2001 . Jahrestagung der Gesellschaft für Virologie, Dresden, DE, 13.-17.03.2001 .

Längle-Rouault, F; Badihi Asl, S; Günzburg, W.H; Salmons, B (2001): MMTV LTR P2 promoter regulation. 13th International Workshop on Retroviral Pathogenesis, Lugano, CH, 26.-29.10.2001 . 13th International Workshop on Retroviral Pathogenesis, Lugano, CH, 26.-29.10.2001 .

Klein, D; Knapp, E; Fröschl, N; Salmons, B; Günzburg, WH (2001): Gene transfer estimation and optimisation: Interplay between FACS analysis and multiplex real-time PCR. 35-35.-XV. Arbeitstagung: Anwendung der Durchflußzytometrie in der klinischen Zelldiagnostik; APR 4-6, 2001; Regensburg.

Holzmüller, H; Urabl, M; Salmons, B; Günzburg, WH; Renner, M (2001): Improvement of MLV-based retroviral vectors by replacement of the 3´-LTR U3 region by strong constitutive or tumour specific promoters. 64-64.-9th Meeting of the European Society of Gene Therapy; NOV 2-4, 2001; Antalya, Turkey.

Dangerfield, J; Salmons, B; Günzburg, WH (2001): Expression of MMTV env in cells that produce rev. 67-67.-13th International Workshop on Retroviral Pathogenesis; 26.-29.10.2001 ; Lugano.

Kosztolich, B; Hain, J; Gradski, B; Salmons, B; Günzburg, WH; Winiarcyk, S (2001): Die gentherapeutische Behandlung von Mammatumoren beim Hund. Uni Vet Wien Report (2001), 2 1-1.

Günzburg, WH (2001): Veterinarians, academia and industry: shaping the future of veterinary sciences (Guest editorial). Veterinary Sciences Tomorrow (On-line publication) (2) 1-1.

Renner, M; Url, A; Petznek, H; Hanak-Hammerl, A; Stracke, A; Günzburg, WH (2001): Xenotransplantation caniner Mammatumoren in immundefiziente SCID/beige-Mäuse: ein Modell für die Gentherapie von Mamatumoren. Wiener Tierärztliche Monatsschrift (88) 332-338.

Tabotta, W; Klein, D; Hohenadl, C; Salmons, B; Günzburg, WH (2001): Genetic reshuffling reconstitutes functional expression cassettes in retroviral vectors. J Gene Med. 2001; 3(5):418-426

Löhr, M; Hoffmeyer, A; Kröger, J; Freund, M; Hain, J; Holle, A; Karle, P; Knöfel, WT; Liebe, S; Müller, P; Nizze, H; Renner, M; Saller, RM; Wagner, T; Hauenstein, K [and 2 others] (2001): Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma. Lancet. 2001; 357(9268):1591-1592

Karle, P; Renner, M; Salmons, B; Günzburg, WH (2001): Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001; 8(3):220-230
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Indraccolo, S; Minuzzo, S; Roccaforte, F; Zamarchi, R; Habeler, W; Stievano, L; Tosello, V; Klein, D; Günzburg, WH; Basso, G; Chieco-Bianchi, L; Amadori, A (2001): Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors. Blood. 2001; 98(13):3607-3617
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Günzburg, WH; Salmons, B (2001): Novel clinical strategies for the treatment of pancreatic carcinoma. Trends Mol Med. 2001; 7(1):30-37

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