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Effect of dehydroepiandrosterone (DHEA) on hair growth in dogs

Abstract
Androgens are able to stimulate (beard) as well as inhibit (frontal scalp) hair growth in men. The dermal papilla cells function as main regulators producing growth factors. In young men with androgenetic alopecia, elevated concentrations of the weak androgen dehydroepiandrosterone (DHEA) have been found in blood. It could be that DHEA is metabolized within the hair follicles to more potent androgens and thereby inhibiting hair growth. As there is no information available about the effect of DHEA on hair growth in dogs, the metabolism of this hormone will be studied using primary cell culture of canine dermal papilla cells and dermal fibroblasts. The results of this investigation should help to develop a specific therapy of sexual hormone associated alopecia in dogs
Project leader
Bamberg Elmar
Duration
01.12.01-31.10.02
Programme
Hochschuljubiläumsstiftung der Stadt Wien
Type of Research
Basic research
Vetmed Research Units
Institute for Medical Biochemistry
Projekt partner
Ludwig Boltzmann Institut für Veterinärmedizinische Endokrinologie, Veterinärplatz 1, A Wien, Austria
Funded by
Stadt Wien, Wien, Austria
4 Publications

Bamberg, E; Aichinger, A; Wünsch, G (2005): In vitro metabolism of progesterone by canine hair follicle cells. Vet Dermatol. 2005; 16(3):153-155

Bamberg, E; Aichinger, A; Mitteregger, G (2004): In vitro metabolism of dehydroepiandrosterone and testosterone by canine hair follicle cells. Vet Dermatol. 2004; 15(1):19-24

Bratka-Robia, CB; Mitteregger, G; Aichinger, A; Egerbacher, M; Helmreich, M; Bamberg, E (2002): Primary cell culture and morphological characterization of canine dermal papilla cells and dermal fibroblasts. Vet Dermatol. 2002; 13(1):1-6

Mitteregger, G; Egerbacher, M; Bamberg, E (2002): Morphologische und funktionelle Charakterisierung von dermalen Papillenzellen und dermalen Fibroblasten des Hundes in vitro. 15. Tagung der Fachgruppe Physiologie und Biochemie der Deutschen Veterinärmedizinischen Gesellschaft, Wien, Austria, Austria, 27.2.-1.3.2002. 15. Tagung der Fachgruppe Physiologie und Biochemie der Deutschen Veterinärmedizinischen Gesellschaft, Wien, Austria, 27.2.-1.3.2002.

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