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Excitotoxicity and neuroprotection in models of neurodegeneration diseases

Abstract
As a project sponsored by ÖEAD (Acciones Integradas) research in neurodegenerative diseases with the Universitat International de Catalunya, Facultat de Ciències de la Salut, Spain has been established. Given the fact that excitotoxicity is relevant for neurodegenerative processes in Alzheimer´s disease, Parkinson´s disease and motor neuron disorders this collaboration focusses on neuroprotective compounds. Drugs of clinical importance (e.g. dopaminergic agonists), vitamins (vitamin C and E), radical scavengers or cofactors of mitochondrial enzymes (coenzyme Q10) will be analysed for their neuroprotective properties. Neuroprotective effects by the above compounds are described on the basis of cell count, morphometry, transmitter biochemistry (tyrosine hydroxylase) and preservation of integrity of mitochondrial enzymes (complex I, II and IV). The Spanish side investigates neuroprotection against excitotoxicity considering apoptotic cell death and membrane desintegration. Their compound of interest and related substances is CDP-choline, a substance which has been shown to have protective effects in cerebral ischemia and neurodegenerative processes. affecting the lipid composition of cell membranes.
Project leader
Rausch Wolf-Dieter
Duration
09.11.01-31.12.07
Type of Research
Basic research
Vetmed Research Units
Institute for Medical Biochemistry
Projekt partner
Universität Barcelona, Gran Via de les Corts Catalanes, 585, 08007 Barcelona, Spain
Funded by
Österreichischer Austauschdienst (OeAD) GmbH, Wien, Austria
9 Publications

Rausch, W.D; Radad, K; Gille, G; Moldzio, R; Ishige, K (2005): Toxische Effekte von Rotenon in dopaminergen Primärzellkulturen. 4. Deutscher Parkinson-Kongress, Frankfurt/Main, 03.-05.03.2005. 4. Deutscher Parkinson-Kongress, Frankfurt/Main, 03.-05.03.2005.

Moldzio, R; Radad, K; Duvigneau, JC; Kranner, B; Krewenka, C; Piskernik, C; Rausch, WD (2006): Glutamate-induced cell death and formation of radicals can be reduced by lisuride in mesencephalic primary cell culture. J Neural Transm. 2006; 113(9):1095-1105

Rausch, W.D; Radad, K; Moldzio, R; Gille, G (2006): Long-term rotenone toxicity on primary mesencephalic culture. FENS 2006, Wien, Austria, 8.-12.Juli 2006. FENS 2006, Wien, 8.-12.Juli 2006.

Moldzio, R; Kranner, B; Krewenka, C; Rausch, W.D (2006): Glutamate-induced cell loss can be reduced by trans-resveratrol in mesencephalic cell cultures of mice. FENS 2006, Wien, Austria, 8.-12.Juli 2006. FENS 2006, Wien, 8.-12.Juli 2006.

Rausch, W.D; Gille, G; Riederer, P (2003): The Dopaminergic Neuron - A Model System of Parkinson's Disease. 43nd International Neuropsychiatric Pula Symposium, Pula, 18.-21.06.2003. 43nd International Neuropsychiatric Pula Symposium, Pula, 18.-21.06.2003.

Franz, A; König, F; Anglmayer, M; Rausch-Fan, X; Gille, G; Rausch, WD; Lucas, T; Sperr, W; Schedle, A (2003): Cytotoxic effects of packable and nonpackable dental composites. Dent Mater. 2003; 19(5):382-392

Gille, G; Rausch, WD; Hung, ST; Moldzio, R; Ngyuen, A; Janetzky, B; Engfer, A; Reichmann, H (2002): Protection of dopaminergic neurons in primary culture by lisuride. J Neural Transm. 2002; 109(2):157-169

Gille, G; Rausch, WD; Hung, ST; Moldzio, R; Janetzky, B; Hundemer, HP; Kolter, T; Reichmann, H (2002): Pergolide protects dopaminergic neurons in primary culture under stress conditions. J Neural Transm. 2002; 109(5-6):633-643

Gille, G; Janetzky, B; Rausch, W.-D; Engfer, A; Reichmann, H (2001): Lisuride exerts protective effects on dopaminergic neurons in primary culture. XIV International Congress on Parkinson's Disease, Helsinki, Finland, July 28 - August 1, 2001. Parkinsonism & Related Disorders (7), S1 S37-S38.

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