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Stem cell induction in aging rats and mice by fetal tissue material

Abstract
Fetal mesenchymal tissue homogenates from sheep injected subcutaneously has shown to improve survival and age parameters in aged rats and mice, and to delay significantly the expression of spontaneous leukosis in OF1 mice. Both effects may be related to the effects of non-species-specific fetal factors modifying renewal and differentiation of hematopoietic and other adult stem cells. The effect of the material on yac and wehi cells as well as on hematopoetic stem cells and splenocytes of non leukotic and leukotic mice is being tested in vitro.
Project leader
Hofecker Gerhard
Duration
01.03.02-31.03.04
Type of Research
Basic research
Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology, Pathophysiology, and Experimental Endocrinology
Projekt partner
Medizinische Universität Gdansk, Gdansk, Poland
Funded by
3 Publications

Hofecker, G; Strasser, A; Niedermüller, H; Gabler, C (2005): Revitalization and life span extension by xenogenic fetal materials: Laboratory rodent and cell culture studies. Rejuvenation Research 8,(Suppl. 1).

Hofecker, G; Strasser, A; Niedermüller, H; Gabler, C (2005): Revitalization and Lifespan Extension by Xenogenic Fetal Materials: Laboratory Rodent and Cell Culture Studies. IN: Sames, K; Sethe, S; Stolzing, A [Hrsg.]: Extending the Lifespan: Biotechnological, Gerontological and Social Considerations. Biotechnical, Gerontological, and Social Problems. Münster, Berlin, London, Lit Verlag, pp. 189-201.

Hofecker, G; Strasser, A; Niedermüller, H; Skalicky, M; Gabler, C (2003): Revitalisierung und MLP-Verlängerung durch xenogene fetale Faktoren bei Labornagern. -10th Annual Conference and Members´ Meeting der Internationalen Gesellschaft f. Cytobiologische Therapien e.V; OCT 18, 2003; Verona, Italy.

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