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Investigations to determine oxidative damages of cellular DNA in animal and human organs

Abstract
In course of a co-work with the departement of physiology at the Veterinarean University of Vienna, issues concerning the oxidative damages affecting the cellular DNA are attended experimental. Until now, the researches directed to age-dependend orrurence of 8-hydroxy-desoxy-guanosine which is a biomarker of oxidative DNA damage in the organs of very old and young Sprague-Dawley rats.
The experiments will be extended to determine specific repair mechanisms of oxidative DNA lesions and potential exogenous modelizings.

Together with the departement of biochemistry at the Veterinarean Faculty of the University of Lublin (Poland) we worked on the issue of oxidative DNA damage in cattle-placentae in correlation to the process of birth.

In the framework of this cooperation we also worked on the problem of oxidative damage of DNA in human placentae.
Project leader
Dadak Agnes
Duration
01.08.99-31.12.08
Type of Research
Basic research
Vetmed Research Units
Institute of Pharmacology and Toxicology
Projekt partner
Uniwersytet Przyrodniczy w Lublinie, ul. Akademicka 13, Lublin, Poland
Funded by
10 Publications

Lopucki, M; Schmerold, I; Dadak, A; Wiktor, H; Niedermüller, H; Kankofer, M (2005): Low dose magnetic fields do not cause oxidative DNA damage in human placental cotyledons in vitro. Virchows Arch. 2005; 446(6):634-639

Lopucki, M; Schmerold, I; Dadak, A; Wiktor, H; Niedermüller, H; Kankofer, M (2005): Levels of 8-hydroxy-2´-deoxy-guanosine in cellular DNA from human placental tissues exposed to low dose magnetic fields in vitro. 38. Jahrestagung Physiologie und Pathologie der Fortpflanzung, 30. Veterinär-Humanmedizinische Gemeinschaftstagung, Zürich, 10.02.-11.02.2005. 38. Jahrestagung Physiologie und Pathologie der Fortpflanzung, 30. Veterinär-Humanmedizinische Gemeinschaftstagung, Zürich, 10.02.-11.02.2005.

Wiktor, H; Kankofer, M; Schmerold, I; Dadak, A; Lopucki, M; Niedermüller, H (2004): Oxidative DNA damage in placentas from normal and pre-eclamptic pregnancies. Virchows Arch. 2004; 445(1):74-78

Wiktor, H; Kankhofer, M; Schmerold, I; Dadak, A; Lopucki, M; Niedermüller, H (2004): Analytical evidence for oxidative DNA damage in preeclamptic placentas. 37th Annual Meeting on Physiology and Pathology of Reproduction, Munich, Germany, FEB 19-20, 2004. Wiener Tierärztliche Monatsschrift (91), S2 73-73.

Niedermüller, H; Schmerold, I (2002): Influence of Methylation, Cytokines and Aging Upon Oxidative DNA Damage. 13th Wiener Symposium on Experimental Gerontology, Wien, 26.-27.4.2002. 13th Wiener Symposium on Experimental Gerontology, Wien, 26.-27.4.2002.

Niedermüller, H; Schmerold, I (2002): Influence of methylation, cytokines and aging upon oxidative DNA damage. Biogerontology (3), Suppl. 1 81-82.

Kankofe, M; Schmerold, I (2002): Spontaneous oxidative DNA damage in bovine retained and nonretained placental membranes. Theriogenology. 2002; 57(7):1929-1938

Niedermüller, H; Schmerold, I (2001): Repair of oxidative DNA damage. Jahrestagung d.Ges.Biologie d. Alterns, Hamburg, 20.-22. Sept. 2001. Jahrestagung d.Ges.Biologie d. Alterns, Hamburg, 20.-22. Sept. 2001.

Kankofer, M; Schmerold, I (2001): Oxidative DNA damage in placental DNA is influenced by the Mode of Delivery in Cows. 5th Annual Conf. of the Eur. Soc. of Domestic Animal Repro.(ESDAR), Vienna, 13.-15. Sept. 2001. 5th Annual Conf. of the Eur. Soc. of Domestic Animal Repro.(ESDAR), Vienna, 13.-15. Sept. 2001.

Schmerold, I; Niedermüller, H (2001): Levels of 8-hydroxy-2"-deoxyguanosine in cellular DNA from 12 tissues of young and old Sprague-Dawley rats. Exp Gerontol. 2001; 36(8):1375-1386

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