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Modulation of the ageing process in the rat

Extended studies on the modulation of the ageing processes in the rat by physical exercise and food restriction - Monika Skalicky (University of Veterinary Medicine, Vienna)
The elderly part of the population grows both in numbers and age, which increases the prevalence of chronic degenerative diseases. Life-long keeping of physical fitness and avoidance of overweight are important for preventing a number of age-related diseases. An active life-style also increases life expectancy. Results from studies on animals agree with these findings from population studies. The mechanisms behind the beneficial effects of physical activity and avoidance of overweight are, however, largely unknown.
This project aims at extending from previous projects the analysis of the effects of life-long physical exercise and food restriction on the physiological ageing processes in the male rat from the age of 5 to that of 23 months. Since rats with free access to food grow obese with ageing, food restriction will be used as a model for avoidance of overweight.
In the previous studies we found that physical exercise preserved certain nerve cells in the brain and kept spontaneous activity in an open field setting at a more active level. For this activity also food restriction was beneficial. Now these studies are extended with tests on learning and memory.
Project leader
Skalicky Monika
Type of Research
Applied research
Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology, Pathophysiology, and Experimental Endocrinology
Projekt partner
Contact: Prof. Dr. Andrus Viidik
Contact: Prof. Dr. Konrad Schauenstein
Karl-Franzens-Universität Graz, Graz, Austria
Contact: Prof. Dr. Peter Pietschmann
Universität Wien, Universitätsring 1, 1010 Wien, Austria
Funded by
FWF - Fonds zur Förderung der wissenschaftlichen Forschung, Sensengasse 1, 1090 Wien, Austria
11 Publications

Bodnar, M; Skalicky, M; Viidik, A; Erben, RG (2012): Interaction between exercise, dietary restriction and age-related bone loss in a rodent model of male senile osteoporosis. Gerontology. 2012; 58(2):139-149

Erben, RG; Skalicky, M; Hansalik, M; Viidik, A (2006): Long-term effects of exercise and food restriction on bone mass and bone geometry in rats. International Conference on Progress in Bone and Mineral Research, Vienna, Austria, Austria, November 16–18, 2006. Bone (39), 5 S34-S34.

Pietschmann, P; Skalicky, M; Kneissel, M; Rauner, M; Hofbauer, G; Stupphann, D; Viidik, A (2007): Bone structure and metabolism in a rodent model of male senile osteoporosis. Exp Gerontol. 2007; 42(11):1099-1108

Schraml, E; Quan, P; Stelzer, I; Fuchs, R; Skalicky, M; Viidik, A; Schauenstein, K (2007): Norepinephrine treatment and aging lead to systemic and intracellular oxidative stress in rats. Exp Gerontol. 2007; 42(11):1072-1078

Strasser, A; Dedoyard, A; Lohninger, A; Niedermüller, H (2006): L-Carnitine L-tartrate (LCLT) and dehydroepiandrosterone sulfate (DHEAS) affect red and white blood cells in aged Sprague-Dawley rats. Arch Gerontol Geriatr. 2006; 44(3):325-336

Strasser, A; Skalicky, M; Viidik, A (2006): Impact of moderate physical exercise--in comparison with dietary restrictions--on age-associated decline in cell-mediated immunity of Sprague-Dawley rats. Aging Clin Exp Res. 2006; 18(3):179-186

Skalicky M (2006): Modulation of the ageing process in the rat. Wien, VUW, pp. 18.

Skalicky, M (2006): What can we learn from animal models?. 18th Nordic Congress of Gerontology, Jyväskylä, Finnland, Finland, 28.-31. Mai 2006. 18th Nordic Congress of Gerontology, Jyväskylä, Finnland, 28.-31. Mai 2006.

Hansalik, M; Skalicky, M; Viidik, A (2006): Impairment of water maze behaviour with ageing is counteracted by maze learning earlier in life but not by physical exercise, food restriction or housing conditions. Exp Gerontol. 2006; 41(2):169-174

Niedermüller, H (2003): Apoptose und die Modulation des Alternsprozesses. 10th Annual Conference and Members´ Meeting der Internationalen Gesellschaft f. Cytobiologische Therapien e.V. am 18.10.2003 in Verona. ,

Lohninger, S (2001): Der positive Einfluß von L-Carnitin auf Transkription und Aktivität der Carnitinpalmitoyltransferase I (CPT1) und den Alterungsprozess bei Spraque Dawley Ratten. Dissertation, Vet. Med. Univ. Wien, pp. 93.

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