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Evolution of gene expression in Drosophila

Variation in gene expression is a major source of phenotypic diversity. This proposal takes advantage of the potential of next generation sequencing for comparative gene expression profiling. By measuring gene expression in males and females in seven species, this proposal will address 5 fundamental questions: 1) Evolution of sex-biased gene expression, 2) Evolution of cis- and trans-effects 3) Evolution of alternative splicing, 4) Influence of temperature stress on gene expression 5) Phylogenetic turnover of gene expression intensities.
Statistik Austria science classification
106012         Evolutionary research
106013         Genetics
106023         Molecular biology
Alternative splicing
Copy number variation
Next generation sequencing
Sex-biased gene expression
Genexpr. Drosophila
Project leader
Schlötterer Christian
FWF Einzelprojekte
Type of Research
Basic research
Vetmed Research Units
Institute of Population Genetics
Funded by
FWF - Fonds zur Förderung der wissenschaftlichen Forschung, Wien, Austria

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11 Publications

Wallner, B; Palmieri, N; Vogl, C; Rigler, D; Bozlak, E; Druml, T; Jagannathan, V; Leeb, T; Fries, R; Tetens, J; Thaller, G; Metzger, J; Distl, O; Lindgren, G; Rubin, CJ [and 7 others] (2017): Y Chromosome Uncovers the Recent Oriental Origin of Modern Stallions. Curr Biol. 2017; 27(13):2029-2035.e5

Jakšić, AM; Schlötterer, C (2016): The Interplay of Temperature and Genotype on Patterns of Alternative Splicing in Drosophila melanogaster. Genetics. 2016; 204(1):315-325
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Chen, J; Nolte, V; Schlötterer, C (2015): Temperature stress mediates decanalization and dominance of gene expression in Drosophila melanogaster. PLoS Genet. 2015; 11(2):e1004883
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Chen, J; Nolte, V; Schlötterer, C (2015): Temperature-Related Reaction Norms of Gene Expression: Regulatory Architecture and Functional Implications. Mol Biol Evol. 2015; 32(9):2393-2402
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Schlötterer, C (2015): Genes from scratch--the evolutionary fate of de novo genes. Trends Genet. 2015; 31(4):215-219
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Palmieri, N; Nolte, V; Chen, J; Schlötterer, C (2015): Genome assembly and annotation of a Drosophila simulans strain from Madagascar. Mol Ecol Resour. 2015; 15(2):372-381

Palmieri, N; Kosiol, C; Schlötterer, C (2014): The life cycle of Drosophila orphan genes. Elife. 2014; 3:e01311
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Suvorov, A; Nolte, V; Pandey, RV; Franssen, SU; Futschik, A; Schlötterer, C (2013): Intra-specific regulatory variation in Drosophila pseudoobscura. PLoS One. 2013; 8(12):e83547
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Pandey, RV; Schlötterer, C (2013): DistMap: a toolkit for distributed short read mapping on a Hadoop cluster. PLoS One. 2013; 8(8):e72614
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Pandey, RV; Franssen, SU; Futschik, A; Schlötterer, C (2013): Allelic imbalance metre (Allim), a new tool for measuring allele-specific gene expression with RNA-seq data. Mol Ecol Resour. 2013; 13(4):740-745
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Palmieri, N; Nolte, V; Suvorov, A; Kosiol, C; Schlötterer, C (2012): Evaluation of different reference based annotation strategies using RNA-Seq - a case study in Drososphila pseudoobscura. PLoS One. 2012; 7(10):e46415
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