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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Fallbericht

Publikationsjahr: 2006

AutorInnen: Sipos, W; Gerner, W; Schilcher, F; Leeb, C; Groiss, S; Miller, I; Saalmüller, A; Schmoll, F; Schwendenwein, I

Titel: Immunophenotypic characterization of peripheral blast cells in a leukemic miniature pig.

Quelle: Vet Pathol. 2006; 43(3):362-367



Autor/innen der Vetmeduni Vienna:

Gerner Wilhelm
Leeb Christine
Miller Ingrid
Saalmüller Armin
Schilcher Franz
Schmoll Friedrich
Schwendenwein Ilse
Sipos Wolfgang

Beteiligte Vetmed-Organisationseinheiten
Institut für Immunologie
Institut für Medizinische Biochemie
Institut für Pathologie
Plattform Labordiagnostik
Universitätsklinik für Schweine
VetFarm


Abstract:
The health status of a 4-year-old female, dd-haplotype miniature pig deteriorated rapidly, so the animal finally had to be euthanized because of poor clinical condition. Necropsy revealed a massive leukocytic infiltration in the parenchymatous organs of the abdominal cavity. On hematologic cell counting, severe leukocytosis (69.3 x 10(9) cells/liter) and high-grade basophilia (6.9 x 10(9) cells/liter) were evident. Cytologic examination, as well as analysis of expression of leukocyte differentiation antigens by means of flow cytometry, classified blasts, which accounted for about 22% of leukocytes, as biphenotypic cells co-expressing the myeloid marker SWC3 (CD172a) and the lymphoid markers CD5 and CD25. Hematologic features resembled those seen in humans with chronic myeloid leukemia at blast phase.

Keywords Pubmed: Animals
Female
Immunophenotyping
Leukemia/immunology
Leukemia/metabolism
Leukemia/pathology
Leukemia/veterinary*
Leukocytes/immunology
Leukocytes/metabolism*
Liver/pathology
Ovary/pathology
Swine
Swine Diseases/blood*
Swine Diseases/immunology*
Swine Diseases/metabolism
Tumor Markers, Biological/metabolism


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