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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 1991

AutorInnen: Saalmüller, A; Weiland, F; Reddehase, MJ

Titel: Resting porcine T lymphocytes expressing class II major histocompatibility antigen.

Quelle: Immunobiology (183), 1-2 102-114.


Autor/innen der Vetmeduni Vienna:

Saalmüller Armin

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
The immune system of swine is unique in that the expression of CD4 and CD8 antigens defines four subpopulations of resting, extrathymic (CD1-) T lymphocytes in the circulation as well as in lymphoid tissue. Here it is documented that the specialty of the porcine T lymphocyte compartment extends to the expression of class II MHC (SLA) antigens. While the TCR-gamma/delta CD4-CD8- as well as the TCR-alpha/beta CD4+CD8- subpopulation both lack MHC II, the TCR-alpha/beta CD4-CD8+ and the CD4+CD8+ subpopulation, the latter of which is private to swine, both do express MHC II. As opposed to human T lymphocytes, expression of porcine MHC II is not transient and restricted to lymphoblasts but is immanent in small, resting T lymphocytes of the two CD8-expressing subsets, even though also in swine activation can induce MHC II. Activation-induced extrathymic acquisition of MHC II without reversal can be discussed as one possible way of how MHC II+ T lymphocytes are generated. Alternatively, MHC II antigens should already be expressed by thymic progenitors. Remarkably, all CD1+CD4-CD8+ and most CD1+CD4+CD8+ thymocytes lack MHC II, yet, a minor subset with the phenotype CD4hiCD8hi expresses MHC II. One may speculate that these cells do not undergo thymic selection and represent the progenitors of the unusual, swine-typic MHC II+CD4+CD8+ extrathymic T lymphocytes.

Keywords Pubmed: Animals - : Antigens, CD4 - immunology : Antigens, CD8 - immunology : Flow Cytometry - immunology : Histocompatibility Antigens Class II - biosynthesis : Lymphocyte Activation - biosynthesis : Major Histocompatibility Complex - immunology : Receptors, Antigen, T-Cell, alpha-beta - immunology : Receptors, Antigen, T-Cell, gamma-delta - immunology : Stem Cells - immunology : Swine - immunology : T-Lymphocyte Subsets - immunology : T-Lymphocytes - immunology : Thymus Gland - immunology : Up-Regulation - immunology

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