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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2015

AutorInnen: Metzler-Zebeli, BU; Eberspächer, E; Grüll, D; Kowalczyk, L; Molnar, T; Zebeli, Q

Titel: Enzymatically Modified Starch Ameliorates Postprandial Serum Triglycerides and Lipid Metabolome in Growing Pigs.

Quelle: PLoS One. 2015; 10(6):e0130553



Autor/innen der Vetmeduni Vienna:

Eberspächer-Schweda Eva
Kowalczyk Lidia
Metzler-Zebeli Barbara
Zebeli Qendrim

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierernährung und funktionelle Pflanzenstoffe
Universitätsklinik für Kleintiere, Klinische Abteilung für Anästhesiologie und perioperative Intensivmedizin
Universitätsklinik für Schweine


Zugehörige(s) Projekt(e): Etablierung eines aussagekräftigen in-vivo Modells zur Einstufung gesundheitsfördernder Wirkungen von Kohlehydraten


Abstract:
Developing host digestion-resistant starches to promote human health is of great research interest. Chemically modified starches (CMS) are widely used in processed foods and although the modification of the starch molecule allows specific reduction in digestibility, the metabolic effects of CMS have been less well described. This short-term study evaluated the impact of enzymatically modified starch (EMS) on fasting and postprandial profiles of blood glucose, insulin and lipids, and serum metabolome in growing pigs. Eight jugular-vein catheterized pigs (initial body weight, 37.4 kg; 4 months of age) were fed 2 diets containing 72% purified starch (EMS or waxy corn starch (control)) in a cross-over design for 7 days. On day 8, an 8-hour meal tolerance test (MTT) was performed with serial blood samplings. Besides biochemical analysis, serum was analysed for 201 metabolites through targeted mass spectrometry-based metabolomic approaches. Pigs fed the EMS diet showed increased (P<0.05) immediate serum insulin and plasma glucose response compared to pigs fed the control diet; however, area-under-the-curves for insulin and glucose were not different among diets. Results from MTT indicated reduced postprandial serum triglycerides with EMS versus control diet (P<0.05). Likewise, serum metabolome profiling identified characteristic changes in glycerophospholipid, lysophospholipids, sphingomyelins and amino acid metabolome profiles with EMS diet compared to control diet. Results showed rapid adaptations of blood metabolites to dietary starch shifts within 7 days. In conclusion, EMS ingestion showed potential to attenuate postprandial raise in serum lipids and suggested constant alteration in the synthesis or breakdown of sphingolipids and phospholipids which might be a health benefit of EMS consumption. Because serum insulin was not lowered, more research is warranted to reveal possible underlying mechanisms behind the observed changes in the profile of serum lipid metabolome in response to EMS consumption.

Keywords Pubmed: Animal Feed
Animals
Blood Glucose/analysis
Diet
Dietary Carbohydrates/pharmacology*
Digestion/physiology
Insulin/blood
Lipid Metabolism
Male
Metabolome/drug effects*
Postprandial Period/physiology*
Starch/chemistry
Starch/metabolism*
Starch/pharmacology
Swine
Triglycerides/blood*


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