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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2016

AutorInnen: Loncaric, I; Beiglböck, C; Feßler, AT; Posautz, A; Rosengarten, R; Walzer, C; Ehricht, R; Monecke, S; Schwarz, S; Spergser, J; Kübber-Heiss, A

Titel: Characterization of ESBL- and AmpC-Producing and Fluoroquinolone-Resistant Enterobacteriaceae Isolated from Mouflons (Ovis orientalis musimon) in Austria and Germany.

Quelle: PLoS One. 2016; 11(5):e0155786



Autor/innen der Vetmeduni Vienna:

Beiglböck Christoph
Kübber-Heiss Anna
Loncaric Igor
Posautz Annika
Rosengarten Renate
Spergser Joachim
Walzer Christian

Beteiligte Vetmed-Organisationseinheiten
Forschungsinstitut für Wildtierkunde und Ökologie, Conservation Medicine
Forschungsinstitut für Wildtierkunde und Ökologie
Institut für Mikrobiologie


Abstract:
The aim of this study was to investigate the presence of β-lactamase producing or fluoroquinolone-resistant members of the family Enterobacteriaceae in European mouflons (Ovis orientalis musimon). The mouflon samples originated from nasal and perineal swabs and/or organ samples in cases of a suspected infection. Only one of the 32 mouflons was tested positive for the presence of Enterobacteriaceae that displayed either an ESBL/AmpC phenotype or were resistant to ciprofloxacin. The positively tested swab originated from a sample of the jejunal mucosa of a four-year old female mouflon. Two different colony morphotypes were identified as Escherichia coli and Klebsiella pneumoniae. These isolates were phenotypically and genotypically characterized in detail by a polyphasic approach. Both isolates were multi-drug resistant. The E. coli isolate belonged to the phylogenetic group B1 and sequence type (ST) 744 and harboured the β-lactamase genes blaCTX-M-15 and blaOXA-1. The K. pneumoniae, identified as ST11, harboured the β-lactamase genes blaSHV-11, blaOXA-1, and blaDHA-1 as well as the plasmid-mediated quinolone resistance (PMQR) gene qnrB55. The present study demonstrates that wild animals can acquire human-derived resistance determinants and such findings may indicate environmental pollution with resistance determinants from other sources.

Keywords Pubmed: Animals
Anti-Bacterial Agents/pharmacology*
Bacterial Proteins/genetics
Bacterial Proteins/metabolism*
Drug Resistance, Bacterial*
Enterobacteriaceae/drug effects
Enterobacteriaceae/enzymology*
Enterobacteriaceae/genetics
Enterobacteriaceae/isolation & purification
Female
Gastrointestinal Microbiome
Jejunum/microbiology
Quinolones/pharmacology*
Sheep/microbiology
beta-Lactamases/genetics
beta-Lactamases/metabolism*


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