Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc

Grafischer Link zur Startseite der Vetmeduni Vienna

Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2017

AutorInnen: Kluger, R; Burgstaller, J; Vogl, C; Brem, G; Skultety, M; Mueller, S

Titel: Candidate gene approach identifies six SNPs in tenascin-C (TNC) associated with degenerative rotator cuff tears.

Quelle: J Orthop Res. 2017; 35(4):894-901



Autor/innen der Vetmeduni Vienna:

Brem Gottfried
Burgstaller Jörg
Müller Simone
Vogl Claus

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierzucht und Genetik, Abteilung für Molekulare Genetik
Institut für Tierzucht und Genetik, Abteilung für Reproduktionsbiologie


Abstract:
Evidence for a heritable predisposition to rotator cuff tears (RCTs) is growing. Unrelated Caucasian individuals with surgically diagnosed full thickness RCTs (cases) and elderly Caucasian controls with intact rotator cuffs were screened for differences at the candidate genes: TNC, Col5A1, TIMP-1, MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13. A first cohort (59 cases; 32 controls) was genotyped with the Sequenom MassARRAY iPLEX system. Of 142 SNPs within about 67-kbp of the TNC gene, 30 were tested for differences in proportions between cases and controls. A second, matched cohort (96 patients; 44 controls) was also genotyped for the same 30 SNPs, but with the KASP™ genotyping technology. Combining the two cohorts and after Bonferroni correction, six SNPs were significantly associated with RCT. Compared to controls, RCT patients showed a significantly higher rate of homozygosity at rs72758637, rs7021589, and rs1138545; a significantly higher rate of heterozygosity at rs10759753, rs3789870, and rs7035322 and a higher minor allele frequency at rs3789870. Rs1138545, a missense SNP in exon10 might be of biological significance because it varies the amino acid sequence close to the TNC-FNIII5 domain. The FNIII5 domain binds multiple growth factors and co-ligates with integrins during tendon healing. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:894-901, 2017.

Keywords Pubmed: Aged
Alleles
Case-Control Studies
European Continental Ancestry Group
Exons
Female
Genetic Predisposition to Disease
Genotype
Humans
Joint Diseases/genetics
Linkage Disequilibrium
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide*
Rotator Cuff/pathology
Rotator Cuff Injuries/genetics*
Sequence Analysis, DNA
Tenascin/genetics*


© Veterinärmedizinische Universität Wien Hilfe und Downloads