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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2008

AutorInnen: Arshad, N; Zitterl-Eglseer, K; Hasnain, S; Hess, M

Titel: Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry.

Quelle: Phytother Res. 2008; 22(11):1533-1538

Autor/innen der Vetmeduni Vienna:

Hess Michael
Zitterl-Eglseer Karin

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierernährung und funktionelle Pflanzenstoffe
Universitätsklinik für Geflügel und Fische

In the present study the antimicrobial potential of various extracts from 12 medicinal plants has been investigated in vitro on multiple antibiotic resistant pathogens and some selected protozoa isolated from poultry. The initial examination was performed on E. coli (n = 10) using disc and agar well diffusion assays. Only two plants, Peganum harmala (seeds) and Eucalyptus globulus (leaves) showed positive responses. The active extracts were also investigated against an additional 19 bacteria and the clonal cultures of three protozoa (Histomonas meleagridis, Tetratrichomonas gallinarum and Blastocystis sp.). Only Peganum harmala was found to inhibit the growth of all bacteria and protozoa at 0.38-1.55 mg/mL and 0.63-1.65 mg/mL, respectively. To investigate the potential role of alkaloids in crude extracts of Peganum harmala, four known beta-carbolin alkaloids were quantified and their antimicrobial activity was compared using a microdilution assay. Harmaline was found to be in the highest concentration followed by harmine and harmalol, whereas harmane could not be detected. The activity of the pure alkaloids was in the order harmane > harmaline > harmalol > or = harmine for all bacteria, while for protozoa, it was different depending on the microorganism. It is concluded that Peganum harmala or its alkaloids could probably be used for the control of antibiotic resistant isolates of bacteria as well as protozoa.

Keywords Pubmed: Animals
Anti-Bacterial Agents/pharmacology
Antiprotozoal Agents/pharmacology
Bacteria/drug effects*
Drug Resistance
Eukaryota/drug effects*
Harmaline/analogs & derivatives*
Harmine/analogs & derivatives*
Microbial Sensitivity Tests
Parasitic Sensitivity Tests
Plant Extracts/pharmacology
Plants, Medicinal/chemistry

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