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Gewählte Publikation:

[Article in Press]

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2021

AutorInnen: Austin, S; Nowikovsky, K

Titel: Mitochondrial osmoregulation in evolution, cation transport and metabolism.

Quelle: Biochim Biophys Acta Bioenerg. 2021; 148368

Autor/innen der Vetmeduni Vienna:

Nowikovsky Karin

Beteiligte Vetmed-Organisationseinheiten
Institut für Physiologie, Pathophysiologie und Biophysik, Abteilung für Physiologie und Biophysik

Zugehörige(s) Projekt(e): Charakterisierung des neuen LETM1 Interaktionspartner TMBIM5

Cross-Communication between Succinate Dehydrogenase and Fatty Acid Biosynthesis

This review provides a retrospective on the role of osmotic regulation in the process of eukaryogenesis. Specifically, it focuses on the adjustments which must have been made by the original colonizing α-proteobacteria that led to the evolution of modern mitochondria. We focus on the cations that are fundamentally involved in volume determination and cellular metabolism and define the transporter landscape in relation to these ions in mitochondria as we know today. We provide analysis on how the cations interplay and together maintain osmotic balance that allows for effective ATP synthesis in the organelle.Copyright © 2021. Published by Elsevier B.V.

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