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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2017

AutorInnen: Lukasch, B; Westerdahl, H; Strandh, M; Winkler, H; Moodley, Y; Knauer, F; Hoi, H

Titel: Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system.

Quelle: PeerJ. 2017; 5:e3679



Autor/innen der Vetmeduni Vienna:

Hoi Herbert,
Knauer Felix,
Moodley Yoshan,
Winkler Hans,

Beteiligte Vetmed-Organisationseinheiten
Conservation Medicine, Forschungsinstitut für Wildtierkunde und Ökologie
Konrad Lorenz Institut für Vergleichende Verhaltensforschung,


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Abstract:
A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what extent the highly polymorphic MHC is involved in interactions of the innate and adaptive immune defence and if specific functional MHC alleles (FA) or heterozygosity at the MHC are more important.


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