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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2018

AutorInnen: Ribitsch, I; Peham, C; Ade, N; Dürr, J; Handschuh, S; Schramel, JP; Vogl, C; Walles, H; Egerbacher, M; Jenner, F

Titel: Structure-Function relationships of equine menisci.

Quelle: PLoS One. 2018; 13(3):e0194052

Autor/innen der Vetmeduni Vienna:

Egerbacher Monika,
Handschuh Stephan,
Jenner Florien,
Peham Christian,
Ribitsch Iris,
Schramel Johannes,
Vogl Claus,

Beteiligte Vetmed-Organisationseinheiten
Abteilung für Molekulare Genetik,
Institut für Pathologie und Gerichtliche Veterinärmedizin,
Klinische Abteilung für Interne Medizin Pferde,
Klinische Abteilung für Pferdechirurgie,

Meniscal pathologies are among the most common injuries of the femorotibial joint in both human and equine patients. Pathological forces and ensuing injuries of the cranial horn of the equine medial meniscus are considered analogous to those observed in the human posterior medial horn. Biomechanical properties of human menisci are site- and depth- specific. However, the influence of equine meniscus topography and composition on its biomechanical properties is yet unknown. A better understanding of equine meniscus composition and biomechanics could advance not only veterinary therapies for meniscus degeneration or injuries, but also further substantiate the horse as suitable translational animal model for (human) meniscus tissue engineering. Therefore, the aim of this study was to investigate the composition and structure of the equine knee meniscus in a site- and age-specific manner and their relationship with potential site-specific biomechanical properties. The meniscus architecture was investigated histologically. Biomechanical testing included evaluation of the shore hardness (SH), stiffness and energy loss of the menisci. The SH was found to be subjected to both age and site-specific changes, with an overall higher SH of the tibial meniscus surface and increase in SH with age. Stiffness and energy loss showed neither site nor age related significant differences. The macroscopic and histologic similarities between equine and human menisci described in this study, support continued research in this field.

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