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Gewählte Publikation:

[Article in Press]

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2018

AutorInnen: Hartmann, C; Gerner, W; Walter, I; Saalmüller, A; Aurich, C

Titel: Influences of intrauterine semen administration on regulatory T lymphocytes in the oestrous mare (Equus caballus).

Quelle: Theriogenology. 2018; 118:119-125



Autor/innen der Vetmeduni Vienna:

Aurich Christine,
Gerner Wilhelm,
Hartmann Constanze,
Saalmüller Armin,
Walter Ingrid,

Beteiligte Vetmed-Organisationseinheiten
Institut für Immunologie,
Institut für Pathologie und Gerichtliche Veterinärmedizin,
Plattform Besamung und Embryotransfer,


Abstract:
In the mare, early pregnancy loss is common, but involvement of the maternal immune system in the pathogenesis of this condition has not been investigated in detail so far. In the present study, we assessed effects of exposure of the endometrium to semen or seminal plasma in oestrous mares on the response of regulatory T lymphocytes (Tregs) in the peripheral circulation as well as in the endometrium. Raw semen, seminal plasma or PBS (control) were introduced into the uterus of oestrous mares (n = 12). Blood was collected immediately before insemination or PBS infusion (time 0), and 12, 24 and 48 h thereafter. Endometrial biopsies were collected at 24 h. In peripheral blood, Treg (CD4


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