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Gewählte Publikation:

[Article in Press]

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2018

AutorInnen: Endler, L; Gibert, JM; Nolte, V; Schlötterer, C

Titel: Pleiotropic effects of regulatory variation in tan result in correlation of two pigmentation traits in Drosophila melanogaster.

Quelle: Mol Ecol. 2018;



Autor/innen der Vetmeduni Vienna:

Endler Lukas,
Nolte Viola,
Schlötterer Christian,

Beteiligte Vetmed-Organisationseinheiten
Institut für Populationsgenetik,
Plattform Bioinformatik und Biostatistik,


Zugehörige(s) Projekt(e): Kartierung mittels neuer Hochdurchsatzsequenzierung


Abstract:
Traits with a common genetic basis frequently display correlated phenotypic responses to selection or environmental conditions. In Drosophila melanogaster pigmentation of the abdomen and a trident-shaped region on the thorax are genetically correlated. Here, we used a pooled replicated genome-wide association approach (Pool-GWAS) to identify the genetic basis of variation in thoracic trident pigmentation in two Drosophila melanogaster populations. We confirmed the previously reported large effect of ebony and the association of the cosmopolitan inversion In(3R)Payne. For the first time, we identified tan as another major locus contributing to variation in trident pigmentation. Intriguingly, the regulatory variants of tan that were most strongly associated with female abdominal pigmentation also showed a strong association with trident pigmentation. We validated this common genetic basis in transgenic assays and found qualitatively similar effects on trident and abdominal pigmentation. Further work is required to determine whether this genetic correlation is favored by natural selection or reflects a neutral by-product of a shared regulatory architecture. This article is protected by copyright. All rights reserved.


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