Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc

Grafischer Link zur Startseite der Vetmeduni Vienna

Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2002

AutorInnen: Petznek, H; Kappler, R; Scherthan, H; Müller, M; Brem, G; Aigner, B

Titel: Reduced body growth and excessive incisor length in insertional mutants mapping to mouse Chromosome 13.

Quelle: Mamm Genome. 2002; 13(9):504-509



Autor/innen der Vetmeduni Vienna:

Aigner Bernhard,
Brem Gottfried,
Müller Mathias,
Petznek Helga,

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierzucht und Genetik,
Interuniversitäres Department für Agrarbiotechnologie (IFA),


Abstract:
Phenotypic and molecular genetic examinations of a transgenic mouse line showing developmental defects caused by a recessive insertional mutation were carried out. The mutant phenotype is characterized by general retardation of postnatal body growth and by the appearance of increased incisor length in the upper and lower jaw. The mutation causing the aberrant phenotype was mapped to Chromosome 13, 40 cM. Examination of the expression of the candidate genes did not show any alterations. This mutant mouse line provides a reproducible model for the identification and examination of gene(s) involved in growth and in the craniofacial development, including that of the jaws and teeth.

Keywords Pubmed: Animals
Body Constitution/genetics
Chromosome Mapping
Craniofacial Abnormalities/genetics
Female
Growth Disorders/genetics*
Heterozygote
Homozygote
Incisor/abnormalities*
Incisor/growth & development
Male
Mice
Mice, Inbred BALB C
Mice, Transgenic
Mutagenesis, Insertional
Phenotype


© Veterinärmedizinische Universität Wien Hilfe und Downloads