Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc

Grafischer Link zur Startseite der Vetmeduni Vienna

Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 1999

AutorInnen: Reichart, U; Renner-Muller, I; Kappler, R; Scherthan, H; Wolf, E; Muller, M; Brem, G; Aigner, B

Titel: Novel leptin receptor gene deficient animal model caused by an insertional mutation in transgenic mice.

Quelle: Arch Tierzucht 1999; 42: 153-155.


Autor/innen der Vetmeduni Vienna:

Aigner Bernhard,
Brem Gottfried,
Müller Mathias,

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierzucht und Genetik,


Abstract:
Examination of random insertional mutations in transgenic animals harbouring an abnormal phenotype contributes to the discovery of new genes and/or the understanding of the function of already known genes. We revealed a partial deletion of the leptin receptor (Ob-R) gene in a transgenic mouse line harbouring an insertional mutation. In the homozygous mutant mice of the outbred strain used, a strong variation of the obesity and diabetes phenotype was observed. The leptin receptor defective mice of this line might serve as a model for the investigation of genes modulating the development and mode of expression of diabetes.


© Veterinärmedizinische Universität Wien Hilfe und Downloads