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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2010

AutorInnen: Morina, R; Knorr, C; Haase, B; Leeb, T; Seuberlich, T; Zurbriggen, A; Brem, G; Schütz, E; Brenig, B

Titel: Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.

Quelle: Anim Genet. 2010; 41(1):85-88



Autor/innen der Vetmeduni Vienna:

Brem Gottfried,

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierzucht und Genetik,


Abstract:
Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrP(C) into the pathogenic PrP(d). Six sequence variants within the CHST8 gene were identified by comparative sequencing and genotyped for a sample of 623 animals comprising bovine spongiform encephalopathy (BSE)-affected and healthy control cows representing German Fleckvieh (German Simmental), German Holstein (Holstein-Friesian) and Brown Swiss. Significant differences in the allele, genotype and haplotype frequencies between BSE-affected and healthy cows indicate an association of sequence variant g.37254017G>T with the development of the disease in Brown Swiss cattle.

Keywords Pubmed: Animals
Cattle/genetics*
Encephalopathy, Bovine Spongiform/genetics*
Encephalopathy, Bovine Spongiform/metabolism
Genetic Predisposition to Disease*
PrPC Proteins/metabolism
Sulfotransferases/genetics*
Sulfotransferases/metabolism


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