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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2010

AutorInnen: Gotic, I; Leschnik, M; Kolm, U; Markovic, M; Haubner, BJ; Biadasiewicz, K; Metzler, B; Stewart, CL; Foisner, R

Titel: Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.

Quelle: Circ Res. 2010; 106(2):346-353



Autor/innen der Vetmeduni Vienna:

Kolm Ursula,
Leschnik Michael,
Markovic Mato,

Beteiligte Vetmed-Organisationseinheiten
Klinische Abteilung für Interne Medizin Kleintiere,


Abstract:
Lamina-associated polypeptide (LAP)2alpha is a mammalian chromatin-binding protein that interacts with a fraction of A-type lamins in the nuclear interior. Because mutations in lamins and LAP2alpha lead to cardiac disorders in humans, we hypothesized that these factors may play important roles in heart development and adult tissue homeostasis.

Keywords Pubmed: Adrenergic beta-Agonists/pharmacology
Animals
Blotting, Western
DNA-Binding Proteins/deficiency
DNA-Binding Proteins/genetics
DNA-Binding Proteins/physiology*
Dystrophin/genetics
Dystrophin/metabolism
Dystrophin/physiology
Echocardiography/drug effects
Female
Fibrosis
GATA4 Transcription Factor/genetics
GATA4 Transcription Factor/metabolism
Gene Expression Regulation, Developmental
Heart/embryology
Heart/growth & development
Heart/physiopathology*
Isoproterenol/pharmacology
MEF2 Transcription Factors
Male
Membrane Proteins/deficiency
Membrane Proteins/genetics
Membrane Proteins/physiology*
Mice
Mice, Inbred C57BL
Mice, Inbred mdx
Mice, Knockout
Myocardium/metabolism
Myocardium/pathology
Myogenic Regulatory Factors/genetics
Myogenic Regulatory Factors/metabolism
Reverse Transcriptase Polymerase Chain Reaction
Ventricular Dysfunction, Left/genetics
Ventricular Dysfunction, Left/physiopathology


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