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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2007

AutorInnen: Zitterl, W; Aigner, M; Stompe, T; Zitterl-Eglseer, K; Gutierrez-Lobos, K; Schmidl-Mohl, B; Wenzel, T; Demal, U; Zettinig, G; Hornik, K; Thau, K

Titel: [123I]-beta-CIT SPECT imaging shows reduced thalamus-hypothalamus serotonin transporter availability in 24 drug-free obsessive-compulsive checkers.

Quelle: Neuropsychopharmacology. 2007; 32(8):1661-1668



Autor/innen der Vetmeduni Vienna:

Zitterl-Eglseer Karin

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierernährung und funktionelle Pflanzenstoffe


Abstract:
Numerous findings indicate alterations in brain serotonin systems in obsessive-compulsive disorder (OCD). We investigated the in vivo availability of thalamus-hypothalamus serotonin transporters (SERT) in patients with DSM-IV OCD who displayed prominent behavioral checking compulsions (OC-checkers). Four hours after injection of [(123)I]-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([(123)I]-beta-CIT), single photon emission computed tomography (SPECT) scans were performed in 24 medication-free non-depressed OC-checkers and 24 age- and gender-matched healthy controls. For quantification of brain serotonin transporter availability, a ratio of specific to non-displaceable [(123)I]-beta-CIT brain binding was used (V""(3)=(thalamus and hypothalamus-cerebellum)/cerebellum). Drug-free non-depressed OC-checkers showed an 18% reduced brain serotonin transporter availability in the thalamus and hypothalamus, as compared with healthy control subjects (1.38+/-0.19 vs 1.69+/-0.21; p<0.001). There was a strong negative correlation between severity of OC symptomatology (Y-BOCS scores) and SERT availability (r=-0.80; p<0.001). Moreover, we found a significant positive correlation between illness duration and serotonin transporter availability (r=0.43; p<0.05). This first report of significantly reduced [(123)I]-beta-CIT binding in the thalamus-hypothalamus region in OC-checkers suggests reduced brain serotonin transporter availability, which is more pronounced with increased severity of OC symptomatology and short duration of illness. The results provide direct evidence for an involvement of the serotonergic system in the pathophysiology of OCD.

Keywords Pubmed: Adult
Case-Control Studies
Cocaine/analogs & derivatives
Cocaine/diagnostic use
Cocaine/pharmacokinetics
Female
Humans
Hypothalamus/drug effects
Hypothalamus/metabolism
Hypothalamus/radionuclide imaging*
Male
Middle Aged
Obsessive-Compulsive Disorder*/diagnosis
Obsessive-Compulsive Disorder*/pathology
Obsessive-Compulsive Disorder*/radionuclide imaging
Protein Binding/drug effects
Radiopharmaceuticals/diagnostic use
Radiopharmaceuticals/pharmacokinetics
Serotonin Plasma Membrane Transport Proteins/metabolism*
Statistics, Nonparametric
Thalamus/drug effects
Thalamus/metabolism
Thalamus/radionuclide imaging*
Tomography, Emission-Computed, Single-Photon/methods*


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