Publizierter (zitierfähiger) Beitrag für wissenschaftliche Veranstaltung in Proceedings (A2)
Handling of dietary antigens - nutritional interactions with the gut immune system.
EAAP Public. 283-291.-International Symposium on Energy and Protein Metabolism and Nutrition; SEP 13-18, 2003; Rostock, Germany. IN: Souffrant, WB [Hrsg.]: Progress in research on energy and protein metabolism. (EAAP publication ; 109);
The gut mucosa is exposed to numerous exogenous factors and has differentiated regulatory mechanisms, that enable selective permeability for nutrients and certain macromolecules but also exclusion of potentially harmful dietary, environmental or bacterial antigens. Discrimination of absorption and exclusion, tolerance and reactivity is resulting from complex regulatory processes that are depending on the age of the individual, the functional and regulatory mechanisms of the immune system and the influence of exogenous factors. The interaction between luminal factors of dietary or bacterial origin and the gut wall is of particular importance. Exogenous food antigens, e.g. peptides, glycoproteins and lectins, but also microorganisms have the ability of interacting with the gut wall and to induce reactions and regulatory and counter regulatory processes. The interaction of luminal factors with the gut wall influences digestion (secretion, absorption, motility), immunological mechanisms (exclusion of antigens, regulation of the GI immune system, on the other hand antigen processing, sensitivity, allergy), and neuro-endocrine processes and integration. Nutrition has significant impact on the gastrointestinal tract of young animals and is of special importance for the function of the gut and the associated immune system during early growth phase and later in adulthood.