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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2011

AutorInnen: Compaoré, M; Lamien-Meda, A; Mogoşan, C; Lamien, CE; Kiendrebeogo, M; Voştinaru, O; Vlase, L; Ionescu, C; Nacoulma, OG

Titel: Antioxidant, diuretic activities and polyphenol content of Stereospermum kunthianum Cham. (Bignoniaceae).

Quelle: Nat Prod Res. 2011; 25(19):1777-1788



Autor/innen der Vetmeduni Vienna:

Lamien-Meda Aline

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierernährung und funktionelle Pflanzenstoffe


Abstract:
Stereospermum kunthianum was used for biological and phytochemical investigations. In biological studies, antioxidant activities were investigated with water, methanol and aqueous acetone extracts. Furthermore, the xanthine oxidase inhibitory activity and the diuretic activity of an aqueous acetone extract were evaluated. In the phytochemical investigations, the flavonoids and polyphenols were quantified spectrophotometrically in all extracts followed by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis of an aqueous acetone extract. The 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP) and 2,2"-azinobis (3-ethylbenzoline-6-sulphonate (ABTS) methods have shown that the aqueous acetone extract presents the best antioxidant activities. This aqueous acetone extract was further proven to have interesting xanthine oxidase inhibitory activity, but only a weak diuretic activity. This aqueous acetone extract also possessed the highest phenolic and flavonoid contents. HPLC-MS analysis allowed identifying and quantifying, rutin, isoquercitrin, quercetin, hyperoside, quercitrin and luteolin and the glycosides of ferulic, sinapic p-coumaric acids and kaempferol, apigenin in aqueous-acetone extract.

Keywords Pubmed: Acetone
Animals
Antioxidants/chemistry
Antioxidants/pharmacology*
Bignoniaceae/chemistry*
Biphenyl Compounds/antagonists & inhibitors
Chromatography, High Pressure Liquid
Diuretics/chemistry
Diuretics/pharmacology*
Flavonoids/analysis
Inhibitory Concentration 50
Male
Mass Spectrometry
Methanol
Picrates/antagonists & inhibitors
Plant Extracts/chemistry
Plant Extracts/pharmacology*
Polyphenols/analysis
Potassium/urine
Rats
Rats, Wistar
Sodium/urine
Spectrophotometry
Uric Acid/urine
Water
Xanthine Oxidase/metabolism


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