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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2012

AutorInnen: Khol-Parisini, A; Hellweg, P; Razzazi-Fazeli, E; Saalmüller, A; Strasser, A; Tichy, A; Zenteke, J

Titel: Highly deoxynivalenol contaminated oats and immune function in horses.

Quelle: Arch Anim Nutr. 2012; 66(2):149-161



Autor/innen der Vetmeduni Vienna:

Khol Annabella
Razzazi-Fazeli Ebrahim
Saalmüller Armin
Strasser Alois
Tichy Alexander
Zentek Jürgen

Beteiligte Vetmed-Organisationseinheiten
Institut für Physiologie, Pathophysiologie und Biophysik, Abteilung für Physiologie, Pathophysiologie und experimentelle Endokrinologie
Institut für Immunologie
Institut für Tierernährung und funktionelle Pflanzenstoffe
Plattform Bioinformatik und Biostatistik


Abstract:
The aim of the present study was to investigate the impact of deoxynivalenol (DON) on cellular and humoral immune parameters in horses. A feeding trial using naturally contaminated oats with high (20.2 mg/kg) and low (0.49 mg/kg) levels of DON was conducted. Two groups of five mares were fed 2 kg oats daily with high or low DON levels for two weeks, using a crossover design with a three-week wash-out period. No adverse effects on general health were observed. Only minor diet-related changes in differential blood counts and serum biochemistry were noted. Serum haptoglobin concentration was significantly elevated after feeding DON (p = 0.04). Lymphocyte subsets (CD4+ CD8+, CD2+, CD21+, MHCII+) and lymphocyte proliferation data (concanavalin A, phytohemagglutinin, pokeweed mitogen) were not different between feeding-groups. It can be concluded that daily DON intakes as high as 6.9 to 9.5 mg/100 kg BW appear to have no major impact on the measured immune response of horses, indicating that this species has a high tolerance for DON.

Keywords Pubmed: Animal Feed/analysis*
Animals
Avena sativa/chemistry*
Cross-Over Studies
Diet/veterinary
Female
Food Contamination/analysis*
Horse Diseases/chemically induced*
Horse Diseases/immunology
Horses
Immunity, Cellular/drug effects
Immunity, Humoral/drug effects
Trichothecenes/chemistry*
Trichothecenes/toxicity*


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