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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 1984

AutorInnen: Tempel, K; Schmerold, I; Pfahler, W; Goette, A

Titel: [Comparative studies on the DNA synthesis of rat thymus and spleen cells in vitro under the influence of x rays, UV light and radiomimetic compounds].

Quelle: Strahlentherapie. 1984; 160(6):386-393


Autor/innen der Vetmeduni Vienna:

Schmerold Ivo

Beteiligte Vetmed-Organisationseinheiten
Institut für Pharmakologie und Toxikologie


Abstract:
In order to further characterize the different repairing behavior of thymus and spleen cells of rats in vitro under the influence of X-rays, UV radiation and methylmethanesulfonate (MMS), the effect of bleomycin (BM), L-cysteine (CY-E), N-ethylmaleimide (NEM), 1-beta-D-arabinofuranosylcytosine (araC), dideoxythymidine (ddT), and novobiocin (NB) on the semiconservative and restorative DNA synthesis as well as on the behavior of DNA under the alkaline elution was studied. The semiconservative DNA synthesis was inhibited by all examined agents except ddT, the restorative DNA synthesis only by NEM, araC, and NB. The stimulation of the restorative DNA synthesis was increased by UV radiation and MMS in spleen cells and by X-rays, BM and CY-E in thymus cells. Under the conditions of alkaline elution, there was a more sensitive reaction of spleen cells than of thymus cells to X-rays, BM and CY-E. The results show that thymus cells are especially qualified for the repair of short chains and spleen cells for the repair of long chains.

Keywords Pubmed: Animals
Bleomycin/pharmacology
Cysteine/pharmacology
Cytarabine/pharmacology
DNA/biosynthesis*
DNA Repair
Ethylmaleimide/analogs & derivatives
Female
Novobiocin/pharmacology
Rats
Spleen/metabolism
Spleen/radiation effects*
Thymidine/metabolism
Thymus Gland/metabolism
Thymus Gland/radiation effects*
Tritium
Ultraviolet Rays
X-Rays


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