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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2003

AutorInnen: Steinrigl, A; Klein, D

Titel: Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics.

Quelle: J Gen Virol. 2003; 84(Pt 5):1301-1307

Autor/innen der Vetmeduni Vienna:

Klein Dieter
Steinrigl Adolf

Beteiligte Vetmed-Organisationseinheiten
Institut für Virologie

Zugehörige(s) Projekt(e): Virus-Wirt Interaktionen

Feline immunodeficiency virus (FIV) is a worldwide-occurring lentivirus that severely impairs the immune function of infected domestic cats. Due to structural and biological similarities, FIV represents a promising model for human immunodeficiency virus (HIV) and AIDS. A major obstacle in developing vaccines against lentiviruses is their high mutation rate. Furthermore, mutations in target sequences provide a pitfall for molecular diagnostics. It is therefore important to determine the genetic diversity of lentiviruses in any region where vaccination or implementation of new diagnostic techniques are planned. This study presents a phylogenetic analysis of 30 FIV strains derived from Central Europe. In order to improve the reliability of genotyping, DNA from two different proviral genes was amplified and comparative phylogenetic trees were inferred. The highly coincident results point to the existence of extensive virus variation with the presence of at least two highly divergent subtypes of FIV in Austria and Germany.

Keywords Pubmed: Animals
Cat Diseases/diagnosis
Cat Diseases/virology*
Feline Acquired Immunodeficiency Syndrome/diagnosis
Feline Acquired Immunodeficiency Syndrome/virology*
Immunodeficiency Virus, Feline/classification*
Immunodeficiency Virus, Feline/genetics*
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Analysis, DNA
Viral Vaccines

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