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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2008

AutorInnen: Meister, T; Lussy, H; Bakonyi, T; Sikutová, S; Rudolf, I; Vogl, W; Winkler, H; Frey, H; Hubálek, Z; Nowotny, N; Weissenböck, H

Titel: Serological evidence of continuing high Usutu virus (Flaviviridae) activity and establishment of herd immunity in wild birds in Austria.

Quelle: Vet Microbiol. 2008; 127(3-4):237-248



Autor/innen der Vetmeduni Vienna:

Bakonyi Tamas
Frey Hans
Lussy Helga
Nowotny Norbert
Vogl Wolfgang
Weissenböck Herbert
Winkler Hans

Beteiligte Vetmed-Organisationseinheiten
Institut für Parasitologie
Institut für Pathologie
Institut für Virologie
Konrad Lorenz Institut für Vergleichende Verhaltensforschung


Zugehörige(s) Projekt(e): Kontinuierliche Überwachung der Usutu Virus Infektion in Österreich - geographische Ausbreitung, empfängliche Spezies und Erkennung von Fällen beim Menschen


Abstract:
Usutu virus (USUV), family Flaviviridae, has been responsible for avian mortality in Austria from 2001 to 2006. The proportion of USUV-positive individuals among the investigated dead birds decreased dramatically after 2004. To test the hypothesis that establishment of herd immunity might be responsible, serological examinations of susceptible wild birds were performed. Blood samples of 442 wild birds of 55 species were collected in 4 consecutive years (2003--2006). In addition, 86 individuals from a birds of prey rehabilitation centre were bled before, at the peak, and after the 2005 USUV transmission season in order to identify titre dynamics and seroconversions. The haemagglutination inhibition test was used for screening and the plaque reduction neutralization test for confirmation. While in the years 2003 and 2004 the proportion of seropositive wild birds was <10%, the percentage of seroreactors raised to >50% in 2005 and 2006. At the birds of prey centre, almost three quarters of the owls and raptors exhibited antibodies before the 2005 transmission season; this percentage dropped to less than half at the peak of USUV transmission and raised again to almost two thirds after the transmission season. These data show a from year to year continuously increasing proportion of seropositive wild birds. The owl and raptor data indicate significant viral exposure in the previous season(s), but also a number of new infections during the current season, despite the presence of antibodies in some of these birds. Herd immunity is a possible explanation for the significant decrease in USUV-associated bird mortalities in Austria during the recent years.

Keywords Pubmed: Animals
Animals, Wild/virology
Antibodies, Viral/blood*
Austria/epidemiology
Bird Diseases/epidemiology*
Bird Diseases/mortality
Bird Diseases/virology
Birds
Encephalitis Viruses, Japanese/immunology*
Encephalitis Viruses, Japanese/isolation & purification
Encephalitis, Arbovirus/epidemiology
Encephalitis, Arbovirus/veterinary*
Encephalitis, Arbovirus/virology
Flavivirus Infections/epidemiology
Flavivirus Infections/veterinary*
Flavivirus Infections/virology
Hemagglutination Inhibition Tests/methods
Hemagglutination Inhibition Tests/veterinary
Longitudinal Studies
Neutralization Tests/methods
Neutralization Tests/veterinary
Raptors/virology
Reverse Transcriptase Polymerase Chain Reaction/veterinary
Seasons
Sentinel Surveillance/veterinary
Seroepidemiologic Studies
Strigiformes/virology


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