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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2004

AutorInnen: Velde, K; Ross, MW; Orsini, JA; Parente, EJ; Foley, B; Richardson, DW; Miselis, RR

Titel: Tracing axons of peripheral nerves in rats: a potential technique to study the equine recurrent laryngeal nerve.

Quelle: J Invest Surg. 2004; 17(3):151-162

Autor/innen der Vetmeduni Vienna:

Velde Karsten

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!

To study the fascicular anatomy of peripheral nerves, three different groups of retrograde axonal tracers were evaluated: fluorophores, horseradish peroxidase conjugated to subunit B of cholera toxin (CT-HRP), and adeno-associated virus (AAV). The hindlimb nerves in rats served as a model to identify the most efficient tracer in regard to labeling axons within peripheral nerves. The rat"s tibial and common peroneal nerves were injected with the different tracers and the sciatic nerve was subsequently examined for evidence of labeled axons. The CT-HRP clearly provided the best results in this rat model. Subsequently, CT-HRP was injected into the recurrent laryngeal nerve (RLN) of two horses in order to identify the location and distribution pattern of the RLN axons within the course of the cervical vagus nerve trunk. No labeling could be observed in either of the two horses.

Keywords Pubmed: Animals
Axons/drug effects*
Cholera Toxin/pharmacology*
Fluorescent Dyes/pharmacology*
Genetic Vectors/pharmacology*
Horseradish Peroxidase/pharmacology*
Horses/anatomy & histology*
Models, Animal
Peripheral Nerves/anatomy & histology*
Peripheral Nerves/drug effects
Rats, Sprague-Dawley
Recurrent Laryngeal Nerve/anatomy & histology
Recurrent Laryngeal Nerve/drug effects

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