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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2002

AutorInnen: Glösmann, M; Ahnelt, PK

Titel: A mouse-like retinal cone phenotype in the Syrian hamster: S opsin coexpressed with M opsin in a common cone photoreceptor.

Quelle: Brain Res. 2002; 929(1):139-146

Autor/innen der Vetmeduni Vienna:

Glösmann Martin

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!

Previous immunocytochemical, physiological, and molecular studies have reported that the Syrian hamster lacks a shortwave-sensitive (S) cone photopigment but retains circadian responses to ultraviolet (UV) light. Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colocalizes with M opsin immunoreactivity in a common type of cone photoreceptor. S opsin signal within individual cone outer segments is low and continuously decreases from the ventral to dorsal retina. Only double-labeled cones were found. During development, S opsin expression precedes that of M opsin, but there is no indication of transdifferentiation. Our results imply that in the Syrian hamster low levels of S opsin colocalize with M opsin in a common cone phenotype. We suggest that, similar to other murid rodents, the S pigment absorbs maximally in the UV range, and thus may contribute to mediating the circadian response of the Syrian hamster to UV light.

Keywords Pubmed: Animals
Animals, Newborn
Cell Count
Circadian Rhythm/physiology*
Gene Expression/physiology
Light Signal Transduction/physiology*
Protein Isoforms/metabolism
Retinal Cone Photoreceptor Cells/cytology
Retinal Cone Photoreceptor Cells/metabolism*
Retinal Rod Photoreceptor Cells/cytology
Retinal Rod Photoreceptor Cells/metabolism
Rod Opsins/metabolism*
Ultraviolet Rays*

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