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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2012

AutorInnen: Khol-Parisini, A; Hellweg, P; Razzazi-Fazeli, E; Saalmüller, A; Strasser, A; Tichy, A; Zenteke, J

Titel: Highly deoxynivalenol contaminated oats and immune function in horses.

Quelle: Arch Anim Nutr. 2012; 66(2):149-161

Autor/innen der Vetmeduni Vienna:

Khol Annabella
Razzazi-Fazeli Ebrahim
Saalmüller Armin
Strasser Alois
Tichy Alexander
Zentek Jürgen

Beteiligte Vetmed-Organisationseinheiten
Institut für Physiologie, Pathophysiologie und Biophysik, Abteilung für Physiologie, Pathophysiologie und experimentelle Endokrinologie
Institut für Immunologie
Institut für Tierernährung und funktionelle Pflanzenstoffe
Plattform Bioinformatik und Biostatistik

The aim of the present study was to investigate the impact of deoxynivalenol (DON) on cellular and humoral immune parameters in horses. A feeding trial using naturally contaminated oats with high (20.2 mg/kg) and low (0.49 mg/kg) levels of DON was conducted. Two groups of five mares were fed 2 kg oats daily with high or low DON levels for two weeks, using a crossover design with a three-week wash-out period. No adverse effects on general health were observed. Only minor diet-related changes in differential blood counts and serum biochemistry were noted. Serum haptoglobin concentration was significantly elevated after feeding DON (p = 0.04). Lymphocyte subsets (CD4+ CD8+, CD2+, CD21+, MHCII+) and lymphocyte proliferation data (concanavalin A, phytohemagglutinin, pokeweed mitogen) were not different between feeding-groups. It can be concluded that daily DON intakes as high as 6.9 to 9.5 mg/100 kg BW appear to have no major impact on the measured immune response of horses, indicating that this species has a high tolerance for DON.

Keywords Pubmed: Animal Feed/analysis*
Avena sativa/chemistry*
Cross-Over Studies
Food Contamination/analysis*
Horse Diseases/chemically induced*
Horse Diseases/immunology
Immunity, Cellular/drug effects
Immunity, Humoral/drug effects

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