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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Übersichtsarbeit

Jahr: 2007

AutorInnen: Dahan, S; Roth-Walter, F; Arnaboldi, P; Agarwal, S; Mayer, L

Titel: Epithelia: lymphocyte interactions in the gut.

Quelle: Immunol Rev. 2007; 215:243-253



Autor/innen der Vetmeduni Vienna:

Roth-Walter Franziska

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
The mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The intestinal epithelial cell (IEC) sits at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria (LP). The cross talk that occurs between these compartments serves to maintain intestinal homeostasis. IECs have the capacity to talk to LP lymphocytes, activating populations of unique regulatory T cells. These cells have the capacity to talk back to the epithelium, influencing epithelial cell growth and differentiation. This review looks at this cross talk and places it in the context of mucosal immunoregulation.

Keywords Pubmed: Animals
Antigen-Presenting Cells/immunology
Antigen-Presenting Cells/metabolism
Cell Communication/immunology*
Epithelial Cells/immunology*
Epithelial Cells/metabolism
Humans
Immunity, Mucosal*
Intestinal Mucosa/cytology
Intestinal Mucosa/immunology*
Lymphocyte Activation/immunology
Receptor Cross-Talk/immunology*
T-Lymphocytes/immunology*
T-Lymphocytes/metabolism


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