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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2009

AutorInnen: Arnaboldi, PM; Roth-Walter, F; Mayer, L

Titel: Suppression of Th1 and Th17, but not Th2, responses in a CD8(+) T cell-mediated model of oral tolerance.

Quelle: Mucosal Immunol. 2009; 2(5):427-438

Autor/innen der Vetmeduni Vienna:

Roth-Walter Franziska

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!

The role of CD8(+) T cells in oral tolerance remains unclear. To address this, we developed a model to induce CD8(+) Tregs by feeding the major histocompatibility complex class I immunodominant epitope of OVA, OVA((257-264)). OVA((257-264)) feeding induced tolerance similar to that observed in OVA protein-fed mice, capable of suppressing the production of Th1 and Th17 cytokines and inhibiting a Th1-driven delayed-type hypersensitivity response following immunization with whole OVA (wOVA) protein. OVA((257-264)) peptide-induced suppression could be transferred to naive mice with CD8(+) cells, but not CD8-depleted cells, isolated from mesenteric lymph nodes of peptide-fed mice. Interestingly, while capable of inhibiting Th1 and Th17 responses, OVA((257-264)) feeding could not suppress any feature of a Th2 inflammatory response, though OVA protein feeding could, suggesting that these cells function through a different mechanism than their CD4(+) counterparts generated in response to feeding with wOVA. Thus, CD8(+) T cells are functionally capable of mediating tolerance to Th1 and Th17 responses.

Keywords Pubmed: Administration, Intranasal
Administration, Oral
Adoptive Transfer
Alveolitis, Extrinsic Allergic/immunology
Alveolitis, Extrinsic Allergic/pathology
Alveolitis, Extrinsic Allergic/prevention & control*
Antigens/administration & dosage*
CD8-Positive T-Lymphocytes/immunology*
CD8-Positive T-Lymphocytes/transplantation
Desensitization, Immunologic/methods*
Ear, External/immunology
Ear, External/pathology
Immune Tolerance/immunology*
Immunodominant Epitopes/administration & dosage*
Immunodominant Epitopes/immunology
Immunodominant Epitopes/toxicity
Injections, Intradermal
Lymphocyte Cooperation
Mice, Inbred C57BL
Models, Immunological
Ovalbumin/administration & dosage*
Peptide Fragments/administration & dosage
Peptide Fragments/immunology
Peptide Fragments/toxicity
T-Lymphocyte Subsets/immunology
T-Lymphocytes, Helper-Inducer/immunology*
T-Lymphocytes, Regulatory/immunology*

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