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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2005

AutorInnen: Untersmayr, E; Bakos, N; Schöll, I; Kundi, M; Roth-Walter, F; Szalai, K; Riemer, AB; Ankersmit, HJ; Scheiner, O; Boltz-Nitulescu, G; Jensen-Jarolim, E

Titel: Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients.

Quelle: FASEB J. 2005; 19(6):656-658

Autor/innen der Vetmeduni Vienna:

Jensen-Jarolim Erika
Roth-Walter Franziska

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!

Recently, we have demonstrated that anti-ulcer drugs, such as H2-receptor blockers and proton pump inhibitors, promote the development of immediate type food allergy toward digestion-labile proteins in mice. The aim of this study was to examine the allergological relevance of these findings in humans. In an observational cohort study, we screened 152 adult patients from a gastroenterological outpatient clinic with negative case histories for atopy or allergy, who were medicated with H2-receptor blockers or proton pump inhibitors for 3 months. IgE reactivities to food allergens before and after 3 months of anti-acid treatment were compared serologically. Ten percent of the patients showed a boost of preexisting IgE antibodies and 15% de novo IgE formation toward numerous digestion-labile dietary compounds, like milk, potato, celery, carrots, apple, orange, wheat, and rye flour. Thus, the relative risk to develop food-specific IgE after anti-acid therapy was 10.5 (95% confidence interval: 1.44-76.48). The long-term effect was evaluated 5 months after therapy. Food-specific IgE could still be measured in 6% of the patients, as well as significantly elevated serum concentrations of ST2, a Th2-specific marker. An unspecific boost during the pollen season could be excluded, as 50 untreated control patients revealed no changes in their IgE pattern. In line with our previous animal experiments, our data strongly suggest that anti-ulcer treatment primes the development of IgE toward dietary compounds in long-term acid-suppressed patients.

Keywords Pubmed: Adult
Anti-Ulcer Agents/administration & dosage
Anti-Ulcer Agents/adverse effects*
Cohort Studies
Dyspepsia/drug therapy
Food Hypersensitivity/etiology*
Histamine H2 Antagonists/adverse effects
Immunoglobulin E/blood*
Immunoglobulin E/immunology
Membrane Proteins/blood
Proton Pump Inhibitors
Receptors, Cell Surface
Risk Factors
Skin Tests
Time Factors

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