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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2005

AutorInnen: Roth, GA; Moser, B; Krenn, C; Roth-Walter, F; Hetz, H; Richter, S; Brunner, M; Jensen-Jarolim, E; Wolner, E; Hoetzenecker, K; Boltz-Nitulescu, G; Ankersmit, HJ

Titel: Heightened levels of circulating 20S proteasome in critically ill patients.

Quelle: Eur J Clin Invest. 2005; 35(6):399-403



Autor/innen der Vetmeduni Vienna:

Jensen-Jarolim Erika
Roth-Walter Franziska

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Recently, circulating proteasome core particles (20S proteasome) have been suggested as a marker of cell damage and immunological activity in autoimmune diseases. Aberrant leucocyte activation and increased lymphocyte apoptosis with consecutive T-cell unresponsiveness is deemed to play a pivotal role in the sepsis syndrome. Moreover sepsis-induced muscle proteolysis mainly reflects ubiqutin proteasome-dependent protein degradation. We therefore sought to investigate serum levels of 20S proteasome in critical ill patients.

Keywords Pubmed: Adult
Case-Control Studies
Cohort Studies
Critical Illness
Cysteine Endopeptidases/metabolism*
Female
Humans
Male
Middle Aged
Multienzyme Complexes/metabolism*
Proteasome Endopeptidase Complex
Systemic Inflammatory Response Syndrome/blood*
Wounds and Injuries/blood*


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