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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2013

AutorInnen: Watkins, JD; Sholukh, AM; Mukhtar, MM; Siddappa, NB; Lakhashe, SK; Kim, M; Reinherz, EL; Gupta, S; Forthal, DN; Sattentau, QJ; Villinger, F; Corti, D; Ruprecht, RM

Titel: Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission.

Quelle: AIDS. 2013; 27(9):F13-F20



Autor/innen der Vetmeduni Vienna:

Klein Dieter

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Although passive immunization with anti-HIV-1 Env IgG1 neutralizing monoclonal antibodies (nmAbs) prevented simian-human immunodeficiency virus (SHIV) infection in rhesus monkeys, IgA nmAbs have not been tested. Here, we sought to determine whether human anti-HIV-1 dimeric (d)IgA1, dIgA2, and IgG1 differ in their ability to prevent mucosal R5 SHIV acquisition in rhesus monkeys.

Keywords Pubmed: AIDS Vaccines/administration & dosage*
AIDS Vaccines/immunology
Administration, Rectal
Animals
Antibodies, Monoclonal/immunology
Antibodies, Neutralizing/immunology
HIV Antibodies/immunology
HIV-1/genetics
HIV-1/immunology*
Humans
Immunity, Mucosal/immunology
Immunization, Passive
Immunoglobulin A/immunology*
Intestinal Mucosa/virology
Macaca mulatta
Neutralization Tests
RNA, Viral/blood
Simian Acquired Immunodeficiency Syndrome/prevention & control*
Simian Acquired Immunodeficiency Syndrome/transmission
Simian immunodeficiency virus/immunology*
Transcytosis/drug effects*
Transcytosis/physiology
Viral Load
Virion/immunology*


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