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Gewählte Publikation:

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Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2014

AutorInnen: Palmieri, N; Kosiol, C; Schlötterer, C

Titel: The life cycle of Drosophila orphan genes.

Quelle: Elife. 2014; 3:e01311



Autor/innen der Vetmeduni Vienna:

Kosiol Carolin
Palmieri Nicola
Schlötterer Christian

Beteiligte Vetmed-Organisationseinheiten
Institut für Populationsgenetik


Dryad Logo Daten sind in Dryad abgelegt. | DataLink: http://​dx.doi.org/10.5061/dryad.hq564


Zugehörige(s) Projekt(e): Evolution und Genexpression in Drosophila


Abstract:
Orphans are genes restricted to a single phylogenetic lineage and emerge at high rates. While this predicts an accumulation of genes, the gene number has remained remarkably constant through evolution. This paradox has not yet been resolved. Because orphan genes have been mainly analyzed over long evolutionary time scales, orphan loss has remained unexplored. Here we study the patterns of orphan turnover among close relatives in the Drosophila obscura group. We show that orphans are not only emerging at a high rate, but that they are also rapidly lost. Interestingly, recently emerged orphans are more likely to be lost than older ones. Furthermore, highly expressed orphans with a strong male-bias are more likely to be retained. Since both lost and retained orphans show similar evolutionary signatures of functional conservation, we propose that orphan loss is not driven by high rates of sequence evolution, but reflects lineage-specific functional requirements. DOI: http://dx.doi.org/10.7554/eLife.01311.001.

Keywords Pubmed: Animals
Drosophila/genetics*
Evolution, Molecular
Female
Gene Deletion*
Genes, Insect*
Male


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