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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Letter

Publikationsjahr: 2014

AutorInnen: Blunder, M; Liu, X; Kunert, O; Winkler, NA; Schinkovitz, A; Schmiderer, C; Novak, J; Bauer, R

Titel: Polyacetylenes from Radix et Rhizoma Notopterygii incisi with an inhibitory effect on nitric oxide production in vitro.

Quelle: Planta Med. 2014; 80(5):415-418

Autor/innen der Vetmeduni Vienna:

Novak Johannes
Schmiderer Corinna

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierernährung und funktionelle Pflanzenstoffe

Notopterygium roots (Qiang Huo) have been used in traditional Chinese medicine for treating colds, inflammatory diseases like rheumatoid arthritis, and as an analgesic. The anti-inflammatory activity of the roots of Notopterygium incisum has been evaluated by testing the inhibitory activity on nitric oxide production by inducible nitric oxide synthase. The apparent authenticity of the sample was checked by DNA sequence comparison. Using activity-guided isolation, different compounds were isolated and structurally characterized by means of NMR and mass spectroscopy. Eight polyacetylenes could be identified and were tested on their inhibitory activity on nitric oxide production in RAW 264.7 mouse macrophages using the Griess assay. Different 3-hydroxy allyl polyacetylenes exhibited significant activity (IC50: 8-acetoxyfalcarinol, 20.1 µM; falcarindiol, 9.2 µM; 9-epoxyfalcarindiol, 8.8 µM; and crithmumdiol, 23.6 µM).

Keywords Pubmed: Animals
Cell Line
In Vitro Techniques
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Sequence Data
Nitric Oxide/biosynthesis*
Nitric Oxide Synthase Type II/metabolism
Plant Roots/chemistry*
Polyacetylenes/isolation & purification

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