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Publikationstyp: Zeitschriftenaufsatz
Dokumentart: Originalarbeit

Publikationsjahr: 2014

AutorInnen: Petersen, B; Wulf, HC; Triguero-Mas, M; Philipsen, PA; Thieden, E; Olsen, P; Heydenreich, J; Dadvand, P; Basagaña, X; Liljendahl, TS; Harrison, GI; Segerbäck, D; Schmalwieser, AW; Young, AR; Nieuwenhuijsen, MJ

Titel: Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage.

Quelle: J Invest Dermatol. 2014; 134(11):2806-2813

Autor/innen der Vetmeduni Vienna:

Schmalwieser Alois

Beteiligte Vetmed-Organisationseinheiten
Abteilung für Physiologie und Biophysik

Skin cancer is caused by solar UVR, which is also essential for vitamin D production. DNA damage (thymine dimers: T-T dimers) and vitamin D (25(OH)D) synthesis are both initiated by solar UVB. We aimed to investigate the simultaneous adverse and beneficial effects of solar UVB exposure in holidaymakers. Sun-seekers and skiers (n=71) were observed over 6 days through on-site monitoring, personal diary entries, and recording of personal UVB exposure doses with electronic dosimeters. Urine and blood samples were analyzed for T-T dimers and 25(OH)D, respectively. The volunteers had a statistically significant increase in vitamin D. There were strong associations between UVB exposure and post-holiday levels of T-T dimers and vitamin D, as well as between post-holiday T-T dimers and vitamin D. We conclude that UVB-induced vitamin D synthesis is associated with considerable DNA damage in the skin. These data, on two major health predictors, provide a basis for further field studies that may result in better understanding of the risks and benefits of "real life" solar exposure. However, vitamin D status can be improved more safely through the use of vitamin D dietary supplements.

Keywords Pubmed: Adult
Bathing Beaches
DNA Damage*
Middle Aged
Pyrimidine Dimers/chemistry
Skin/radiation effects
Skin Neoplasms/etiology
Sunlight/adverse effects*
Time Factors
Ultraviolet Rays/adverse effects*
Vitamin D/blood*
Vitamin D Deficiency/prevention & control*
Vitamin D Deficiency/therapy*

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