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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2003

AutorInnen: Fusani, L; Metzdorf, R; Hutchison, JB; Gahr, M

Titel: Aromatase inhibition affects testosterone-induced masculinization of song and the neural song system in female canaries.

Quelle: J Neurobiol (54), 2 370-379.



Autor/innen der Vetmeduni Vienna:

Fusani Leonida

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
Songbirds have a specialized steroid-sensitive network of brain nuclei, the song system, for controlling song. Most nuclei of the song system express androgen receptors, and the sensory-motor integration nucleus High Vocal Center (HVC) alone also expresses estrogen receptors. Apart from expressing estrogen receptors in the vocal control system, songbirds are unique among birds because they have high concentrations of the estrogen-synthesizing enzyme aromatase in the neostriatum surrounding HVC. However, the role of estrogen in controlling the development of the song structure has been scarcely investigated. In this work, we show that blocking the production of estrogen during testosterone-induced song motor development in adult female canaries alters the song pattern compared to control females treated with testosterone only. These effects were correlated with inhibition of the expression of estrogen-sensitive genes, such as brain-derived nerve growth factor, in HVC. The expression of the ATP-synthase gene, an indicator of cell activity, in HVC, and the size of HVC, were not affected by the treatment. Our results provide the first example of estrogen-sensitive mechanisms controlling the structural features of adult birdsong.

Keywords Pubmed: ATP Synthetase Complexes/drug effects
ATP Synthetase Complexes/genetics
Analysis of Variance
Animals
Aromatase/physiology
Aromatase Inhibitors*
Base Sequence
Brain/cytology
Brain/drug effects*
Brain/physiology
Brain-Derived Neurotrophic Factor/drug effects
Brain-Derived Neurotrophic Factor/genetics
Canaries/physiology
Dihydrotestosterone/blood
Drug Implants
Enzyme Inhibitors/pharmacology*
Estradiol/blood
Fadrozole/pharmacology
Female
Gene Expression/drug effects
Gene Expression/physiology
Muscles
Neurons/cytology
Neurons/enzymology
RNA, Messenger/biosynthesis
Receptors, Androgen/biosynthesis
Receptors, Estrogen/biosynthesis
Sound Spectrography/instrumentation
Statistics, Nonparametric
Testosterone/pharmacology*
Vocalization, Animal/drug effects*
Vocalization, Animal/physiology


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