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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2005

AutorInnen: Jansen, R; Metzdorf, R; van der Roest, M; Fusani, L; ter Maat, A; Gahr, M

Titel: Melatonin affects the temporal organization of the song of the zebra finch.

Quelle: FASEB J (19), 7 848-850.



Autor/innen der Vetmeduni Vienna:

Fusani Leonida

Diese Publikation wurde nicht im Namen der Vetmeduni Vienna erstellt und ist deshalb ausschließlich der persönlichen Publikationsliste des/der Autors/Autorin zugeordnet!


Abstract:
In birds and mammals, including humans, melatonin-binding sites are abundant in brain areas that have no known clock function. Although the role of such binding sites is still unclear, it is assumed that these sites link neural functions to circadian or circannual demands of neuroendocrine homeostasis and reproduction. To investigate a possible direct role of melatonin in motor control, we studied the song and neural song system of the zebra finch. Neurons of two sensory-motor areas of the descending song control circuit that are crucial for the organization of the song pattern, the HVC and RA, express the melatonin-1B receptor (Mel1B), while the hypoglossal motor neurons of the song circuit express melatonin-1C receptors (Mel1C). Application of melatonin to brain slices decreases the firing-rate of RA-neurons. Systemic administration of a Mel1B antagonist at the beginning of the night shortens the song and motif length and affects the song syllable lengths produced the next day. The temporal pattern of the song, however, does not undergo daily changes. Thus, melatonin is likely to affect a non-circadian motor pattern by local modulation of song control neurons and in consequence alters a sexual signal, the song of the zebra finch.

Keywords Pubmed: Animals
Base Sequence
Brain/physiology
Brain Chemistry
Chickens
Circadian Rhythm/drug effects*
Cloning, Molecular
Corpus Striatum/chemistry
Corpus Striatum/drug effects
Corpus Striatum/physiology
DNA/chemistry
Finches/physiology*
Humans
Male
Melatonin/pharmacology*
Neurons/physiology
RNA, Messenger/analysis
Receptor, Melatonin, MT2/antagonists & inhibitors
Receptor, Melatonin, MT2/genetics
Receptor, Melatonin, MT2/physiology
Receptors, Melatonin/analysis
Receptors, Melatonin/genetics
Sequence Homology
Vocalization, Animal/drug effects*
Vocalization, Animal/physiology


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