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Gewählte Publikation:

Publikationstyp: Zeitschriftenaufsatz
Dokumenttyp: Originalarbeit

Jahr: 2015

AutorInnen: Ghareeb, K; Awad, WA; Böhm, J; Zebeli, Q

Titel: Impacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine.

Quelle: J Appl Toxicol. 2015; 35(4):327-337

Autor/innen der Vetmeduni Vienna:

Awad Wageha
Böhm Josef
Ghareeb Khaled
Zebeli Qendrim

Beteiligte Vetmed-Organisationseinheiten
Institut für Tierernährung und funktionelle Pflanzenstoffe
Universitätsklinik für Geflügel und Fische, Klinische Abteilung für Geflügelmedizin

Deoxynivalenol (DON) is one of the most prevalent cereal contaminants with major public health concerns owing to its high toxigenic potentials. Once ingested, DON first and foremost targets epithelial cells of the gastrointestinal tract, whose proper functioning, as the first line of defence, is of paramount importance for the host"s health. Emerging evidences, summarized in this article, suggest that DON produces its toxicity primarily via activation of the mitogen-activated protein kinases (MAPKs) signalling pathway and alteration in the expression of genes responsible for key physiological and immunological functions of the intestinal tissue of chickens and pigs. The activation of MAPKs signalling cascade results in disruption of the gut barrier function and an increase in the permeability by reducing expression of the tight junction proteins. Exposure to DON also down-regulates the expression of multiple transporter systems in the enterocytes with subsequent impairment of the absorption of key nutrients. Other major intestinal cytotoxic effects of DON described herein are modulation of mucosal immune responses, leading to immunosupression or stimulation of local immune cells and cytokine release, and also facilitation of the persistence of intestinal pathogens in the gut. Both of the last events potentiate enteric infections and local inflammation in pigs and poultry, rendering enterocytes and the host more vulnerable to luminal toxic compounds. This review highlights the cytotoxic risks associated with the intake of even low levels of DON and also identifies gaps of knowledge that need to be addressed by future research.

Keywords Pubmed: Animal Feed*
Food Contamination*
Foodborne Diseases/etiology
Foodborne Diseases/metabolism
Foodborne Diseases/veterinary*
Intestinal Absorption/drug effects
Intestinal Mucosa/drug effects*
Intestinal Mucosa/enzymology
Intestinal Mucosa/metabolism
Intestines/drug effects
MAP Kinase Signaling System/drug effects
Malabsorption Syndromes/chemically induced
Malabsorption Syndromes/metabolism
Malabsorption Syndromes/veterinary*
Poultry Diseases/chemically induced
Poultry Diseases/enzymology
Poultry Diseases/metabolism
Sus scrofa
Swine Diseases/chemically induced
Swine Diseases/enzymology
Swine Diseases/metabolism

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